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3-Kloropropandiol, 2-Kloropropandiol, Esterleri ve Glisidil Yağ Asidi Esterinin Toksik Etkileri

Year 2019, , 401 - 409, 18.11.2019
https://doi.org/10.24323/akademik-gida.647729

Abstract

3-kloropropandiol (3-MCPD), 2-kloropropandiol
(2-MCPD)
, bunların esterleri ve glisidil yağ
asidi esterleri (GE)
gıda veya gıda işlem kaynaklı bulaşanlar
sınıfında yer almaktadır. İlk olarak, asitle hidrolize olmuş bitkisel
proteinlerde (soya sosu ve sebze proteinleri) tespit edilmiştir. Daha sonraki
yıllarda farklı gıdalarda da 3-MCPD ve esterlerinin varlığının tespit
edilmesiyle bu bileşiklerin güvenliğine yönelik ilgi artmaya başlamıştır. Günümüzde
3-MCPD, 2-MCPD,
bunların yağ asidi esterleri ve GE’nin
en yüksek düzeyde palm yağı olmak üzere hemen hemen tüm bitkisel yağlarda,
margarinlerde, pasta ve kekler gibi birçok işlenmiş gıdada bulunduğu
bilinmektedir. Bu bileşikler aynı zamanda bebek mamalarının içeriğinde de yer
almaktadır. Bu derlemede tüm bu kullanımlar göz önüne alınarak 3-MCPD, 2-MCPD
ve GE’nin toksik etkileri üzerine yapılan çalışmalardan bahsedilmiştir.

References

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Toxic Effects of 3-Chloropropanediol, 2-Chloropropanediol, their Esters and Glycidyl Fatty Acid Ester

Year 2019, , 401 - 409, 18.11.2019
https://doi.org/10.24323/akademik-gida.647729

Abstract

3-chloropropanediol
(3-MCPD), 2-chloropropanediol (2-MCPD), their esters and glycidyl fatty acid
esters (GE) are important food contaminates originating mainly during food
processing. These materials were firstly identified in acid-hydrolyzed plant
proteins such as soybean and other vegetable proteins. Then, the detection of
3-MCPD and its esters in different foods raised interest in the safety profile
of these compounds. Nowadays, 3-MCPD, 2-MCPD and their fatty acid esters and GE
are known to be present in almost all vegetable oils, mostly in palm oil,
margarines and processed foods, especially pastries and cakes. It is also found
in baby foods. In this review, studies on the toxic effects of 3-MCPD, 2-MCPD
and GE are reviewed.

References

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  • [2] EFSA Journal, (2016). Chemicals in Food. Overview of selected data collection. https://www.efsa.europa.eu/sites/default/files/corporate_publications/files/161215chemicalsinfoodreport.pdf (Erişim tarihi: Aralık 2018)
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  • [4] Abraham, K., Appel, K., Berger-Preiss, E., Apel, E., Gerlin, S., Mielke, H., Creutzenberg, O., Lampen, A. (2013). Relative oral bioavailability of 3-MCPD from 3-MCPD fatty acid esters in rats. Archives of Toxicology, 87, 649-59.
  • [5] Cho, W.S., Han, B.S., Lee, H., Kim, C., Nam, K.T., Park, K., Choi, M., Kim, S.J., Kim, S.H., Jeong, J., Jang, D.D. (2008). Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice. Food and Chemical Toxicology, 46, 1666-73.
  • [6] Cho, W.S., Han, B.S., Nam, K.T., Park, K., Choi, M., Kim, S.H., Jeong, J., Jang, D.D. (2008). Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats. Food Chem Toxicol, 46, 3172-77.
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  • [12] Lee, B.Q., Khor, S.M. (2015). 3-Chloropropane-1,2-diol (3-MCPD) in soy sauce: A review on the formation, reduction, and detection of this potential carcinogen. The Comprehensive Reviews in Food Science App, 14(1), 48-66.
  • [13] Velisek, J., Davidek, J., Kubelka, V., Janicek, G., Svobodova, Z., Simicova, Z.(1980). New chlorine-containing organic compounds in protein hydrolysates. Journal of Agricultural and Food Chemistry, 28(6), 1142-1154.
  • [14] Baer, I., de la Calle, B., Taylor, P. (2010). 3-MCPD in food other than soy sauce or hydrolysed vegetable protein (HVP). Anal Bioanal Chem, 396(1), 443-456.
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  • [19] Onami, S., Cho, Y., Toyoda, T., Mizuta, Y., Yoshida, M., Nishikawa, A., Ogawa, K. (2014). A 13-week repeated dose study of three 3-monochloropropane-1,2-diol fatty acid esters in F344 rats. Archives of Toxicology, 88, 871–80.
  • [20] Jones, A.R. (1983). Antifertility actions of alpha-chlorohydrin in the male. Australian Journal of Biological Sciences, 36, 333-350.
  • [21] Stevenson, D., Jones, A. (1984). The action of (R)-and (S)-α-chlorohydrin and their metabolites on the metabolism of boar sperm. International Journal of Andrology, 7, 79-86.
  • [22] WHO, (2002). 3-Chloro-1, 2-Propandiol, WHO Food Add. Ser. 48 Geneva, Switzerland. p. 401-432.
  • [23] El Ramy, R., Ould Elhkim, M., Lezmi, S., Poul, J.M. (2007). Evaluation of the genotoxic potential of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites, glycidol and beta-chlorolactic acid, using the single cell gel/comet assay. Food and Chemical Toxicology, 45(1), 41-48.
  • [24] Robjohns, S., Marshall, R., Fellows, M., Kowalczyk, G. (2003). In vivo genotoxicity studies with 3-monochloropropan-1,2-diol. Mutagenesis, 18(5), 401-404.
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There are 63 citations in total.

Details

Primary Language Turkish
Subjects Food Engineering
Journal Section Review Papers
Authors

Can Özgür Yalçın This is me 0000-0003-4032-3229

Sezen Yilmaz-sarıaltın 0000-0002-8387-4146

Publication Date November 18, 2019
Submission Date September 13, 2017
Published in Issue Year 2019

Cite

APA Yalçın, C. Ö., & Yilmaz-sarıaltın, S. (2019). 3-Kloropropandiol, 2-Kloropropandiol, Esterleri ve Glisidil Yağ Asidi Esterinin Toksik Etkileri. Akademik Gıda, 17(3), 401-409. https://doi.org/10.24323/akademik-gida.647729
AMA Yalçın CÖ, Yilmaz-sarıaltın S. 3-Kloropropandiol, 2-Kloropropandiol, Esterleri ve Glisidil Yağ Asidi Esterinin Toksik Etkileri. Akademik Gıda. November 2019;17(3):401-409. doi:10.24323/akademik-gida.647729
Chicago Yalçın, Can Özgür, and Sezen Yilmaz-sarıaltın. “3-Kloropropandiol, 2-Kloropropandiol, Esterleri Ve Glisidil Yağ Asidi Esterinin Toksik Etkileri”. Akademik Gıda 17, no. 3 (November 2019): 401-9. https://doi.org/10.24323/akademik-gida.647729.
EndNote Yalçın CÖ, Yilmaz-sarıaltın S (November 1, 2019) 3-Kloropropandiol, 2-Kloropropandiol, Esterleri ve Glisidil Yağ Asidi Esterinin Toksik Etkileri. Akademik Gıda 17 3 401–409.
IEEE C. Ö. Yalçın and S. Yilmaz-sarıaltın, “3-Kloropropandiol, 2-Kloropropandiol, Esterleri ve Glisidil Yağ Asidi Esterinin Toksik Etkileri”, Akademik Gıda, vol. 17, no. 3, pp. 401–409, 2019, doi: 10.24323/akademik-gida.647729.
ISNAD Yalçın, Can Özgür - Yilmaz-sarıaltın, Sezen. “3-Kloropropandiol, 2-Kloropropandiol, Esterleri Ve Glisidil Yağ Asidi Esterinin Toksik Etkileri”. Akademik Gıda 17/3 (November 2019), 401-409. https://doi.org/10.24323/akademik-gida.647729.
JAMA Yalçın CÖ, Yilmaz-sarıaltın S. 3-Kloropropandiol, 2-Kloropropandiol, Esterleri ve Glisidil Yağ Asidi Esterinin Toksik Etkileri. Akademik Gıda. 2019;17:401–409.
MLA Yalçın, Can Özgür and Sezen Yilmaz-sarıaltın. “3-Kloropropandiol, 2-Kloropropandiol, Esterleri Ve Glisidil Yağ Asidi Esterinin Toksik Etkileri”. Akademik Gıda, vol. 17, no. 3, 2019, pp. 401-9, doi:10.24323/akademik-gida.647729.
Vancouver Yalçın CÖ, Yilmaz-sarıaltın S. 3-Kloropropandiol, 2-Kloropropandiol, Esterleri ve Glisidil Yağ Asidi Esterinin Toksik Etkileri. Akademik Gıda. 2019;17(3):401-9.

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