Lamellar macular hole following intravitreal aflibercept injection in a patient with neovascular age-related macular degeneration

Year 2023, Volume: 48 Issue: 2, 728 - 732, 02.07.2023

Fatma Bağcı Mehmet Çıtırık

https://doi.org/10.17826/cumj.1229581

Abstract

Purpose: To report a case where a lamellar macular hole (LMH) developed following intravitreal injection of aflibercept due to neovascular age-related macular degeneration (nAMD).

Material and Methods: A 70-year-old man diagnosed with nAMD underwent intravitreal aflibercept injections for three consecutive months. At follow up, the resolution of the subretinal fluid was revealed by optical coherence tomography (OCT), and a visual improvement was observed. One month later, visual impairment occurred with respect to the activation of the neovascular membrane. Hence, intravitreal injection of aflibercept was performed again.

Results: The LMH developed after one month following the last injection, as demonstrated by OCT, in addition to the resolution of subretinal fluid and some visual improvement.

Conclusion: To our knowledge, this is the first case study reporting such LMH formation after intravitreal aflibercept injection. The literature was evaluated for mechanisms in explaining the formation of LMH after aflibercept injection.

Keywords

Aflibercept, age-related macular degeneration intravitreal injection, lamellar macular hole

Neovasküler yaşa bağlı makula dejenerasyonu bulunan bir hastada intravitreal aflibercept enjeksiyonu sonrası lamellar makula deliği gelişimi

Abstract

Keywords

Aflibercept, age-related macular degeneration intravitreal injection, lamellar macular hole

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