Oxidative stress in relation to adenosine deaminase, nitric oxide, nitric oxide synthase and xanthine oxidase in oral cavity cancer

Year 2018, Volume: 4 Issue: 1, 38 - 43, 04.01.2018

Ayca Ant Erdogan Inal Aslihan Avci Metin Genc Umit Tuncel Ziya Sencan Yasemin Genc

https://doi.org/10.18621/eurj.322520

Abstract

Inflammation and oxidative stress
are considered as the main pathways in oral cavity carcinoma. The aim of this study was to evaluate the
activity levels of adenosine deaminase (ADA), nitric oxide (NO),
nitric oxide synthase (NOS), and xanthine oxidase (XO) in oral
cavity carcinoma, to determine their potential roles in carcinogenesis with
relation to oxidative stress. Methods. Seventeen patients with
oral cavity cancer underwent surgery as the primary therapy, were consisted in
the study. Resected oral cavity carcinoma tissues were compared with the
adjacent tumor-free control tissues of the same patients; ADA, NO, NOS, XO
activity levels were evaluated in terms of difference. Results. There is a
significant increase of ADA activity in squamous cell cancer tissues, which
indicates a difference between the normal and tumor tissues at enzyme levels (p<0.001). Conclusion. Elevated ADA activity might be an attempt to
supress formation of the immunosupressed niche which promotes the onset of
neoplasia and/or to inhibit tumor progression and metastasis. 

Keywords

Adenosine deaminase, nitric oxide, nitric oxide synthase, oral cancer, oxidative stress, xanthine oxidase

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