In this study, N,N’-(dodecane-1,12-diyl)bis(2,4-dichlorobenzamide) and N,N’- (dodecane-1,12-diyl)bis(4-bromobenzamide) as new bis-benzamides were syn- thesized by reaction of 1,12-diaminododecane and two different acyl chloride compounds in 88% and 92% yield, respectively. Their molecular structures were characterized using 1H NMR, 13C NMR and FT-IR techniques. Antibacterial activities of the synthesized compounds were screened against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains. Moreover, pho- tophysical properties of the products in CH Cl and CHCl were investigated us-
2 2 3
ing UV-vis spectroscopy. The compound 3a exhibited positive solvatochromism
about 31 nm by increasing of solvent polarity.
Mersin University Research Fund
BAP 2020-1-AP5-4097
This work was funded by Mersin University Research Fund (Project No: BAP 2020-1-AP5-4097).
Bu çalışmada, 1,12-diaminododekan ve iki farklı açil klorür bileşiğinin reaksiyonu ile N,N'-(dodekan-1,12-diil)bis(2,4-diklorobenzamid) ve N,N'-(dodekan-1,12-diil)bis(4-bromobenzamid) olmak üzere yeni bis-benzamidler sırasıyla %88 ve %92 verimle sentezlendi. Moleküler yapıları 1H NMR, 13C NMR ve FT-IR teknikleri kullanılarak karakterize edildi. Sentezlenen bileşiklerin antibakteriyel aktiviteleri Staphylococcus aureus ATCC 25923 ve Escherichia coli ATCC 25922 suşlarına karşı tarandı. Ayrıca, CH2Cl2 ve CHCl3 içindeki ürünlerin fotofiziksel özellikleri UV-vis spektroskopisi kullanılarak incelendi. Bileşik 3a, çözücü polaritesinin artmasıyla yaklaşık 31 nm'de pozitif solvatokromizm gösterdi.
BAP 2020-1-AP5-4097
Primary Language | English |
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Subjects | Pharmacology and Pharmaceutical Sciences |
Journal Section | Research Articles |
Authors | |
Project Number | BAP 2020-1-AP5-4097 |
Publication Date | September 1, 2021 |
Acceptance Date | October 15, 2021 |
Published in Issue | Year 2021 Volume: 41 Issue: 3 |