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Synthesis, characterization and antimicrobial activity of some novel 4-amino-5- phenyl-4H-1,2,4-triazole-3-thiol derivatives

Year 2023, , 294 - 301, 28.12.2023
https://doi.org/10.26650/IstanbulJPharm.2023.1301086

Abstract

Background and aims: The discovery of new antifungals and antimicrobials to overcome resistance has always been a crucial topic for sustainable world health. Since sulfur-containing triazole heterocycles derivatives have shown greater interest due to their valuable applications, we reported herein, the synthesis of some mercaptotriazole derivatives to discover underlying structural requirements for antimicrobial and antifungal activity.

Methods: Firstly, the benzoic acid hydrazide was synthesized. Then it was reacted with carbon disulfide in the solution of alkali ethanol to give potassium dithiocarbazinate salt. Then the basic nucleus 4-amino-5-phenyl-1-4H-1,2,4-triazole-3-thiol was prepared by cyclization of potassium salt with hydrazine hydrate. After that, a condensation reaction with different aldehydes was conducted to synthesize Schiff bases, which were cyclized by treating with thioglycolic acid to prepare desired compounds.

Results: All the synthesized compounds were confirmed by their melting point, FTIR, 1H-NMR, and 13C-NMR spectra, elemental analysis was determined for their antimicrobial activity by using a simple susceptibility screening test with agar-well diffusion. Few compounds showed promising activity against bacteria and yeast-like fungi.

Conclusion: 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol derivatives proved promising antimicrobial activities.

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Year 2023, , 294 - 301, 28.12.2023
https://doi.org/10.26650/IstanbulJPharm.2023.1301086

Abstract

References

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There are 67 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Original Article
Authors

Nurhan Gümrükçüoğlu 0000-0002-9669-6318

Muhammad Imran 0000-0003-1795-1040

Inam Iqbal 0009-0001-5891-8477

Publication Date December 28, 2023
Submission Date May 23, 2023
Published in Issue Year 2023

Cite

APA Gümrükçüoğlu, N., Imran, M., & Iqbal, I. (2023). Synthesis, characterization and antimicrobial activity of some novel 4-amino-5- phenyl-4H-1,2,4-triazole-3-thiol derivatives. İstanbul Journal of Pharmacy, 53(3), 294-301. https://doi.org/10.26650/IstanbulJPharm.2023.1301086
AMA Gümrükçüoğlu N, Imran M, Iqbal I. Synthesis, characterization and antimicrobial activity of some novel 4-amino-5- phenyl-4H-1,2,4-triazole-3-thiol derivatives. iujp. December 2023;53(3):294-301. doi:10.26650/IstanbulJPharm.2023.1301086
Chicago Gümrükçüoğlu, Nurhan, Muhammad Imran, and Inam Iqbal. “Synthesis, Characterization and Antimicrobial Activity of Some Novel 4-Amino-5- Phenyl-4H-1,2,4-Triazole-3-Thiol Derivatives”. İstanbul Journal of Pharmacy 53, no. 3 (December 2023): 294-301. https://doi.org/10.26650/IstanbulJPharm.2023.1301086.
EndNote Gümrükçüoğlu N, Imran M, Iqbal I (December 1, 2023) Synthesis, characterization and antimicrobial activity of some novel 4-amino-5- phenyl-4H-1,2,4-triazole-3-thiol derivatives. İstanbul Journal of Pharmacy 53 3 294–301.
IEEE N. Gümrükçüoğlu, M. Imran, and I. Iqbal, “Synthesis, characterization and antimicrobial activity of some novel 4-amino-5- phenyl-4H-1,2,4-triazole-3-thiol derivatives”, iujp, vol. 53, no. 3, pp. 294–301, 2023, doi: 10.26650/IstanbulJPharm.2023.1301086.
ISNAD Gümrükçüoğlu, Nurhan et al. “Synthesis, Characterization and Antimicrobial Activity of Some Novel 4-Amino-5- Phenyl-4H-1,2,4-Triazole-3-Thiol Derivatives”. İstanbul Journal of Pharmacy 53/3 (December 2023), 294-301. https://doi.org/10.26650/IstanbulJPharm.2023.1301086.
JAMA Gümrükçüoğlu N, Imran M, Iqbal I. Synthesis, characterization and antimicrobial activity of some novel 4-amino-5- phenyl-4H-1,2,4-triazole-3-thiol derivatives. iujp. 2023;53:294–301.
MLA Gümrükçüoğlu, Nurhan et al. “Synthesis, Characterization and Antimicrobial Activity of Some Novel 4-Amino-5- Phenyl-4H-1,2,4-Triazole-3-Thiol Derivatives”. İstanbul Journal of Pharmacy, vol. 53, no. 3, 2023, pp. 294-01, doi:10.26650/IstanbulJPharm.2023.1301086.
Vancouver Gümrükçüoğlu N, Imran M, Iqbal I. Synthesis, characterization and antimicrobial activity of some novel 4-amino-5- phenyl-4H-1,2,4-triazole-3-thiol derivatives. iujp. 2023;53(3):294-301.