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Sarı Kantaron'a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri ve İlaç Etkileşimlerinin İncelenmesi

Year 2021, Volume: 3 Issue: 1, 1 - 37, 31.07.2021

Abstract

Amaç: Bu derleme St. John’s wort olarak bilinen Hypericum perforatum L. bitkisi hakkında bilgiler sunmaktadır. H.perforatum hakkında pek çok çalışma yapılmış, belirli aktiviteler üzerine derlemeler yazılmış olmasına rağmen literatürde sarı kantaron bitkisini kapsamlı olarak ele alan derlemeye rastlanmamıştır. Bu çalışmada bitkinin morfolojik özellikleri, kimyasal bileşimi, bu bileşiklerin terapötik etkileri, etki mekanizmaları, ilaç etkileşimleri ve yan etkileri hakkında detaylı bir derleme oluşturulmuştur. Derlememiz bitkiye ait kapsamlı içeriğiyle farklılık ortaya koymayı amaçlamaktadır.
Metot: Derleme hazırlanırken sağlık alanında uluslararası çalışmaların yayınlandığı PubMed ve Google Scholar veri tabanları kullanılarak 1992-2021 arasında sarı kantaron hakkında yapılan çalışmalardan faydalanılmıştır.
Bulgular: Geçmişten günümüze insanlar bitkilerin tedavi edici özelliklerinden yararlanmıştır. Bitkilerin çeşitli hastalıkları tedavi edici özelliklerinin görülmesi, bilim insanlarını bitkilerin kimyasını araştırmaya yöneltmiştir. Bitkilerdeki biyolojik aktif bileşiklerin ortaya konmasıyla birlikte etken maddeler preklinik ve klinik çalışmalara konu edilmiştir. Bununla birlikte bitkilerin etken maddelerinden ayrışmadan kullanılması da çalışmalarda yer almıştır. Sarı kantaron bitkisi halkımız tarafından terapötik amaçla sıklıkla kullanılan, aynı zamanda pek çok bilimsel araştırmaya konu olmuş, önemli bir bitkidir. Hypericaceae familyasına ait olan bitki parlak sarı, sıklıkla üçlü kümeler şeklinde beş petale sahiptir ve yaprakları, minik saydam yağ bezlerine benzeyen delikler içerir. Aktif major bileşenleri hiperisin ve hiperforindir. Sıklıkla, yara ve yanıkların tedavisinde topikal olarak; depresyon, akut ve kronik ağrı tedavisinde ise oral olarak kullanılmaktadır.
Sonuç: Sarı kantaron bitkisinin vücuttaki çeşitli metabolik yolakları kullanarak pek çok hastalık için terapötik etki potansiyeli sunduğu, bununla birlikte kullanımının ilaç etkileşimleri ve yan etki profili göz önüne alınarak doktor kontrolünde yapılmasının fayda sağlayacağı ortaya konulmuştur.

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References

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About St. John's Wort (Hypericum Perforatum L.): Investigation of Morphology, Mechanisms of Action, Activity, Side Effects and Drug Interactions

Year 2021, Volume: 3 Issue: 1, 1 - 37, 31.07.2021

Abstract

Objective: This review provides information about Hypericum perforatum L., known as St. John's Wort. Although many studies have been conducted on H. perforatum and reviews have been written on certain activities, no comprehensive review of St. John's wort plant has been found in the literature. Our review reveals a difference in the comprehensive content of the plant. In this study, many studies about St. John's Wort have been scanned and a detailed review has been made on the plant's morphological properties, chemical composition, therapeutic effects, mechanisms of action, drug interactions and side effects of these compounds.
Methods: The studies about St. John's Wort plant between 1992 and 2021 were utilized by using PubMed and Google Scholar databases where international studies in the field of health are published.
Results: Humans have benefited from the therapeutic properties of plants from past to present. Observing the therapeutic properties of plants for various diseases has directed scientists to search chemistry of plants. Active pharmaceutical ingredients were achieved with the discovery of biologically active compounds from plants. Hypericum perforatum L. is one of the plants that has been the subject of many studies. However, the use of herbs without separating the active ingredients has also been included in the studies. John's wort plant is an important plant that is frequently used by our people for therapeutic purposes and has also been the subject of many scientific researches. It is perennial herbaceous plant a belonging to the Hypericaceae family. The bright yellow, star-shaped flowers, often clustered in a trio, have five petals and the leafs contain tiny transparent oil glands resembling perforations. The active components of the plant are hypericin and hyperforin. It is generally used internally in the treatment of acute and chronic pain and externally in the treatment of scars and burns.
Conclusions: It has been demonstrating that St. John's Wort plant offers therapeutic effect potential for many diseases by using various metabolic pathways in the body, however, it has been shown that its use will be beneficial under the supervision of a doctor by taking into considering the drug interactions and side effect profile.

Project Number

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References

  • Agostinis, P., Vantieghem, A., Merlevede, W., & de Witte, P. A. M. (2002). Hypericin in cancer treatment: more light on the way. The International Journal of Biochemistry & Cell Biology, 34(3), 221-241. doi:https://doi.org/10.1016/S1357-2725(01)00126-1
  • ANDERSEN, F. A. (2001). Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil. International journal of toxicology, 20, 31-39.
  • Barnes, J., Anderson, L. A., & Phillipson, J. D. (2001). St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. Journal of Pharmacy and Pharmacology, 53(5), 583-600.
  • Barone, G. W., Gurley, B. J., Ketel, B. L., Lightfoot, M. L., & Abul-Ezz, S. R. (2000). Drug interaction between St. John's wort and cyclosporine. Annals of Pharmacotherapy, 34(9), 1013-1016.
  • Bell, E. C., Ravis, W. R., Chan, H. M., & Lin, Y.-J. (2007). Complementary and Alternative Medicine: Lack of Pharmacokinetic Interaction Between St. John's Wort and Prednisone. Annals of Pharmacotherapy, 41(11), 1819-1824.
  • Bell, E. C., Ravis, W. R., Lloyd, K. B., & Stokes, T. J. (2007). Effects of St. John's wort supplementation on ibuprofen pharmacokinetics. Annals of Pharmacotherapy, 41(2), 229-234.
  • Benedı́, J., Arroyo, R., Romero, C., Martı́n-Aragón, S., & Villar, A. M. (2004). Antioxidant properties and protective effects of a standardized extract of Hypericum perforatum on hydrogen peroxide-induced oxidative damage in PC12 cells. Life Sciences, 75(10), 1263-1276.
  • Bolley, R., Zülke, C., Kammerl, M., Fischereder, M., & Krämer, B. K. (2002). Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John’s wort. Transplantation, 73(6), 1009.
  • Bork, P. M., Bacher, S., Schmitz, M. L., Kaspers, U., & Heinrich, M. (1999). Hypericin as a non-antioxidant inhibitor of NF-κB. Planta medica, 65(04), 297-300.
  • Borrelli, F., & Izzo, A. A. (2009). Herb–drug interactions with St John’s wort (Hypericum perforatum): an update on clinical observations. The AAPS journal, 11(4), 710-727.
  • Butterweck, V., & Schmidt, M. (2007). St. John's wort: role of active compounds for its mechanism of action and efficacy. Wiener Medizinische Wochenschrift, 157(13-14), 356-361.
  • Canning, S., Waterman, M., Orsi, N., Ayres, J., Simpson, N., & Dye, L. (2010). The efficacy of Hypericum perforatum (St John’s Wort) for the treatment of premenstrual syndrome. CNS Drugs, 24(3), 207-225.
  • Chang, Y., & Wang, S.-J. (2010). Hypericin, the active component of St. John's wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway. European journal of pharmacology, 634(1-3), 53-61.
  • Chen, X.-W., B Sneed, K., Pan, S.-Y., Cao, C., R Kanwar, J., Chew, H., & Zhou, S.-F. (2012). Herb-drug interactions and mechanistic and clinical considerations. Current drug metabolism, 13(5), 640-651.
  • Chrubasik-Hausmann, S., Vlachojannis, J., & McLachlan, A. J. (2019). Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content. J Pharm Pharmacol, 71(1), 129-138. doi:10.1111/jphp.12858
  • Clewell, A., Barnes, M., Endres, J. R., Ahmed, M., & Ghambeer, D. (2012). Efficacy and tolerability assessment of a topical formulation containing copper sulfate and hypericum perforatum on patients with herpes skin lesions: a comparative, randomized controlled trial. Journal of drugs in dermatology: JDD, 11(2), 209.
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There are 73 citations in total.

Details

Primary Language Turkish
Subjects Public Health, Environmental Health
Journal Section Reviews
Authors

Fatma Şengül 0000-0002-7097-6266

Melikşah Çakır 0000-0002-9220-6190

Beyza Öztürk 0000-0003-0135-7338

Ayşenur Çakmak This is me 0000-0003-2904-6873

Hüsamettin Vatansev 0000-0002-0230-3414

Project Number -
Publication Date July 31, 2021
Submission Date March 13, 2021
Published in Issue Year 2021 Volume: 3 Issue: 1

Cite

APA Şengül, F., Çakır, M., Öztürk, B., Çakmak, A., et al. (2021). Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri ve İlaç Etkileşimlerinin İncelenmesi. Doğal Yaşam Tıbbı Dergisi, 3(1), 1-37.
AMA Şengül F, Çakır M, Öztürk B, Çakmak A, Vatansev H. Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri ve İlaç Etkileşimlerinin İncelenmesi. JNLM. July 2021;3(1):1-37.
Chicago Şengül, Fatma, Melikşah Çakır, Beyza Öztürk, Ayşenur Çakmak, and Hüsamettin Vatansev. “Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri Ve İlaç Etkileşimlerinin İncelenmesi”. Doğal Yaşam Tıbbı Dergisi 3, no. 1 (July 2021): 1-37.
EndNote Şengül F, Çakır M, Öztürk B, Çakmak A, Vatansev H (July 1, 2021) Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri ve İlaç Etkileşimlerinin İncelenmesi. Doğal Yaşam Tıbbı Dergisi 3 1 1–37.
IEEE F. Şengül, M. Çakır, B. Öztürk, A. Çakmak, and H. Vatansev, “Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri ve İlaç Etkileşimlerinin İncelenmesi”, JNLM, vol. 3, no. 1, pp. 1–37, 2021.
ISNAD Şengül, Fatma et al. “Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri Ve İlaç Etkileşimlerinin İncelenmesi”. Doğal Yaşam Tıbbı Dergisi 3/1 (July 2021), 1-37.
JAMA Şengül F, Çakır M, Öztürk B, Çakmak A, Vatansev H. Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri ve İlaç Etkileşimlerinin İncelenmesi. JNLM. 2021;3:1–37.
MLA Şengül, Fatma et al. “Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri Ve İlaç Etkileşimlerinin İncelenmesi”. Doğal Yaşam Tıbbı Dergisi, vol. 3, no. 1, 2021, pp. 1-37.
Vancouver Şengül F, Çakır M, Öztürk B, Çakmak A, Vatansev H. Sarı Kantaron’a Dair (Hypericum Perforatum L.): Morfoloji, Etki Mekanizmaları, Aktivite, Yan Etkileri ve İlaç Etkileşimlerinin İncelenmesi. JNLM. 2021;3(1):1-37.