EMBRİYO İMPLANTASYONUNUN MOLEKÜLER MEKANİZMASI

Year 2019, Volume: 5 Issue: 4, 311 - 322, 30.12.2019

Miyase Erdoğan Elvan Şahin Seher Dinçel

Abstract

İnsan embriyosunun uterus duvarına implantasyonu, blastosist ve reseptif
endometriyum arasındaki karşılıklı etkileşim sonucu gerçekleşir.
Fertilizasyondan yaklaşık 6-7 gün sonra implantasyon başlar. İmplantasyonun
meydana gelebileceği uygun olgunluk düzeyine ulaşmak için, hem blastosist hem
de uterus birbirine paralel olarak farklılaşmalıdır.  Trofoekdoterm (TE)
ile uterus yüzeyini kaplayan lüminal epitel (LE) arasındaki etkileşim,
implantasyonu başlatır. TE ve LE arasındaki ilk bağlantıda bir dizi hücre-yüzey
molekülü rol alır. Bu bileşenlerin rolüne dair kanıtlar tartışmalıdır. Biz de
çalışmamızda implantasyon olayının tüm aşamalarında hangi sinyalizasyon
ağlarının rol aldığını ve implantasyon esnasında meydana gelen olayların
mekanizmalarını moleküler düzeyde literatür bilgisi ışığında derlemeyi
amaçladık.

Keywords

Embriyonik implantasyon, uterus reseptivitesi, hücre yüzey molekülleri, endometriyal sitokinler

MOLECULAR MECHANISM OF EMBRIONIC IMPLANTATION

Abstract

The implantation of the human embryo into
the uterine wall results from the interaction between the blastocyst and the
receptive endometrium. Approximately 6-7 days after fertilization, implantation
begins. Both the blastocyst and the uterus must be differentiated in parallel
to achieve the proper maturity at which implantation can occur. The interaction
between trophoecdotherm (TE) and the luminal epithelium (LE) covering the
uterine surface initiates implantation. A number of cell-surface molecules are
involved in the initial connection between TE and LE. Evidence of the role of
these components is controversial. In this study, we aimed to review which
signaling networks are involved in all stages of implantation and the
mechanisms of events occurring during implantation in the light of the
literature.

Keywords

Embryonic implantation, uterine reseptivity, cell surface molecules, endometrial cytokines

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