Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41
was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO2)
environment. 2-chloro-benzoythiourea modified MCM-41 was prepared
and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections
observed at low angle XRD show the mesoporous SiO2 structure. The
paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET
surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m2/g
2-chloro-benzoythiourea
modified MCM-4, respectively. The absorption and
releasing studies of ibuprofen were caried out in simulated body fluid. The
result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea
modified MCM-41 and slower drug release rate was achieved.
Primary Language | English |
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Subjects | Chemical Engineering |
Journal Section | Articles |
Authors | |
Publication Date | May 15, 2019 |
Submission Date | October 4, 2018 |
Acceptance Date | January 18, 2019 |
Published in Issue | Year 2019 |