A Sensitive Quantification of Agmatine Using a Hybrid Electrode Based on Zinc oxide Nanoparticles

Year 2018, Volume: 5 Issue: 3, 1205 - 1214, 01.09.2018

Hilal İncebay

https://doi.org/10.18596/jotcsa.401450

Cited By: 1

Abstract

An electrochemical sensor was prepared by modifiying a hybrid
of multi-walled carbon nanotubes (MWCNTs) and zinc oxide nanoparticles (ZnONPs)
to a glassy carbon (GC) electrode surface to accurately determine agmatine. The
ZnONPs+MWCNTs/GC electrode surface was characterized using scanning electron
microscopy and energy dispersive X-ray. Agmatine did not exhibit any peak on
the GC electrode surface but exhibited a large oxidation peak at 637.9 mV
on the MWCNT/GC electrode surface. Furthermore, it was observed that the
electrochemical behavior of agmatine was greatly improved on the
MWCNT+ZnONPs/GC electrode surface and that this surface exhibited a
well-defined higher current peak at 581.9 mV. The electrochemical
responses of agmatine on the MWCNT+ZnONPs/GC electrode surface were performed
using square wave voltammetry. A linear plot was obtained for the
current responses of agmatine against concentrations in the range of 0.1 µM–5.2 µM yielding a detection limit
of 4.13×10⁻⁶  M  (based on 3S_b/m). The accurate
quantification of agmatine makes the ZnONPs+MWCNTs/GC electrode system of great
interest for the
treatment of schizophrenia. 

Keywords

Agmatine, zinc oxide nanoparticles, hybrid

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