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Yarış atlarında kullanımı suistimal edilen bazı non-steroidal antienflamatuvar ilaçların biyolojik örneklerden kromatografik yöntemlerle miktar tayini

Year 2012, Volume: 16 Issue: 2, 91 - 106, 07.03.2014

Abstract

Dünya Anti-Doping Ajansı (WADA) tarafından hazırlanan ve güncellenen, yarışmalar
sırasında ve/veya serbest zamanlarda kullanımı yasaklı ilaç gruplarını ve yöntemlerini içeren
listelerde yer almayan, ancak atlarda kullanımı suistimal edilen bazı non-steroidal antienflamatuvar
ilaçların (asetilsalisilik asit, benzidamin, bufeksamak, diklofenak sodyum,
diflunisal, eltenak, etodolak, etorikoksib, felbinak, fenilbutazon, flufenamik asit, fluniksin,
flurbiprofen, ibuprofen, indometazin, indoprofen, karprofen, ketoprofen, ketorolak, meklofenamik
asit, mefenamik asit, meloksikam, mofebutazon, naproksen, niflumik asit, nimesulid,
oksifenbutazon, piroksikam, ramifenazon, selekoksib, sulindak, tenoksikam, tiaprofenik
asit, tolfenamik asit, tolmetin, valdekoksib ve vedaprofen) atlara ait biyolojik örneklerden
hareketle kromatografik yöntemlerle gerçekleştirilen nicel ve nitel analizleri ana hatları
ile derlenmiştir.

References

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  • Dirikolu L, Woods WE, Boyles J, Lehner AF, Harkins JD, Fischer M, Schaeffer DJ, Tobin T. Nonsteroidal an- ti-inflammatory agents and musculoskeletal injuries in thoroughbred racehorses in Kentucky. J Vet Pharmacol Therap 2008; 32:271-79.
  • Bowers LD. The international antidoping system and why it works. Clin Chem 2009; 55:1456-61.
  • National horsemen’s benevolent and protective associa- tion proposed national policy on drug testing and thera- peutic medication. J Equine Vet Sci 2003; 23:18-40.
  • Nicolas-Frey H. International federation of horseracing authorities annual report on prohibited substance. PDF Dokümanı [Erişim Tarihi: 22 Şubat 2012; http://www. ifhaonline.org/resources/2007_Annual_doping_con- trol_annual_report.pdf]
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  • Yücel A, Çimen A. Nöropatik Ağrı: Mekanizmalar, tanı ve tedavi. Ağrı 2005; 17:5-13.
  • Flecknell P. Analgesia from a veterinary perspective. Br J Anaesth 2008; 101:121-24.
  • Muir WW. Pain: Mechanisms and management in hors- es. Vet Clin Equine 2010; 26:467-80.
  • Kızıl Ö. Atlarda sancı ve sancılı atlarda muayene para- metreleri. FÜ Sağ Bil Derg 2007; 21:285-90.
  • Kamerling S, Wood T, DeQuick D, Weckman TJ, Tai C, Blake JW, Tobin T. Narcotic analgesics, their detection and pain measurement in the horse: A review. Equine Vet J 1989; 21:4-12.
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  • Maurer HH. Systematic toxicological analysis proce- dures for acidic drugs and/or metabolites relevant to clinical and forensic toxicology and/or doping control. J Chromatogr B 1999; 733:3-25.
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  • Jaussaud P, Guieu D, Courtot D, Barbier B. Identification of a tolfenamic acid metabolite in the horse by gas chro- matography-mass spectrometry. J Chromatogr 1992; 573:136-40.
  • Laakkonen UM, Leinonen A, Savonen L. Screening of non-steroidal anti-inflammatory drugs, barbiturates and methyl xanthines in equine urine by gas chromatogra- phy-mass spectrometry. Analyst 1994; 119:2695-96.
  • Delbeke FT, Debackere M. A liquid chromatographic method for the determination of fenoprofen in equine plasma and urine. Biomed Chromatogr 1994; 8:29-31.
  • Delbeke FT, Landuyt J, Debackere M. Disposition of hu- man drug preparations in the horse. IV. Orally adminis- tered fenoprofen. J Pharm Biomed Anal 1995; 13:1041-47.
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Year 2012, Volume: 16 Issue: 2, 91 - 106, 07.03.2014

Abstract

References

  • Driessen B. Pain: Systemic and local/regional drug the- raphy. Clin Tech Equine Pract 2007; 6:135-44.
  • Dirikolu L, Woods WE, Boyles J, Lehner AF, Harkins JD, Fischer M, Schaeffer DJ, Tobin T. Nonsteroidal an- ti-inflammatory agents and musculoskeletal injuries in thoroughbred racehorses in Kentucky. J Vet Pharmacol Therap 2008; 32:271-79.
  • Bowers LD. The international antidoping system and why it works. Clin Chem 2009; 55:1456-61.
  • National horsemen’s benevolent and protective associa- tion proposed national policy on drug testing and thera- peutic medication. J Equine Vet Sci 2003; 23:18-40.
  • Nicolas-Frey H. International federation of horseracing authorities annual report on prohibited substance. PDF Dokümanı [Erişim Tarihi: 22 Şubat 2012; http://www. ifhaonline.org/resources/2007_Annual_doping_con- trol_annual_report.pdf]
  • Erdine S. Ağrı. Nobel Tıp Kitabevleri Ltd. Şti., İstanbul, 2007.
  • Yücel A, Çimen A. Nöropatik Ağrı: Mekanizmalar, tanı ve tedavi. Ağrı 2005; 17:5-13.
  • Flecknell P. Analgesia from a veterinary perspective. Br J Anaesth 2008; 101:121-24.
  • Muir WW. Pain: Mechanisms and management in hors- es. Vet Clin Equine 2010; 26:467-80.
  • Kızıl Ö. Atlarda sancı ve sancılı atlarda muayene para- metreleri. FÜ Sağ Bil Derg 2007; 21:285-90.
  • Kamerling S, Wood T, DeQuick D, Weckman TJ, Tai C, Blake JW, Tobin T. Narcotic analgesics, their detection and pain measurement in the horse: A review. Equine Vet J 1989; 21:4-12.
  • Anti-Doping Eğitim ve Doping Kontrolünün Kanuni Yönleri. Editörler: Hıncal AA, Dalkara S, Hacettepe Üniversitesi ISBN 975-491-022-7, Ankara 1991, pp: 83-8.
  • Maurer HH. Role of gas chromatography-mass spec- trometry with negative ion chemical ionization in clini- cal and forensic toxicology, doping control and biomoni- toring. Ther Drug Monit 2002; 24:247-54.
  • Maurer HH. Systematic toxicological analysis proce- dures for acidic drugs and/or metabolites relevant to clinical and forensic toxicology and/or doping control. J Chromatogr B 1999; 733:3-25.
  • Van Eenoo P, Delbeke FT. Criteria in chromatography and mass spectrometry-a comparison between regula- tions in the field of residue and doping analysis. Chro- matographia 2004; 59–Suppl.: 39-44.
  • El Haj BM, Al Ainri AM, Hassan MH, Bin Khadem RK, Marzouq MS. The GC/MS analysis of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) in pharmaceutical dosage forms and in urine. For Sci Int 1999; 105:141-53.
  • Segura J, Ventura R, Jurado C. Derivatization procedures for gas chromatographic-mass spectrometric determina- tion of xenobiotics in biological samples, with special at- tention to drugs of abuse and doping agents. J Chroma- togr B 1998; 713:61-90.
  • Fragkaki AG, Leontiou IP, Kioukia-Fougia N, Tsivou M, Spyridaki MHE, Georgakopoulos CG. Organization of doping control laboratory in the Athens 2004 olympic games. A case study. Technovation 2006; 26:1162-69.
  • Stanley SD, Kollias-Baker C. Review of equine drug test- ing. AAEP Proceedings 1997; 43:211-14.
  • Thevis M, Schanzer W. Current role of LC-MS(/MS) in doping control. Anal Bioanal Chem 2007; 388:1351-58.
  • Moulard Y, Bailly-Chouriberry L, Boyer S, Garcia P, Po- pot MA, Bonnaire Y. Use of benchtop exactive high reso- lution and high mass accuracy orbitrap mass spectrom- eter for screening in horse doping control. Anal Chim Acta 2011; 700:126-36.
  • Peters RJB, Stloker AAM, Mol JGJ, Lommen A, Lyris E, Angelis Y, Vonaparti A, Stamou M, Georgakopoulos C, Nielen MWF. Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry. Trends in Anal Chem 2010; 29:1250-68.
  • You Y, Uboh CE, Soma LR, Guan F, Li X, Liu Y, Chen J, Tsang D. Simultaneous determination of testosterone and testosterone enanthate in equine plasma by UHPLC- MS-MS. Chromatographia 2010; 72:1097-06.
  • Vinci F, Fabbrocino S, Fiori M, Serpe L, Gallo P. Deter- mination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatog- raphy/mass spectrometry. Rapid Commun Mass Spec- trom 2006; 20:3412-20.
  • DeJong EG, Kiffers J, Maes RAA. The determination of non-steroidal anti-inflammatory drugs by GC-MS-MS in equine urine. J Pharm Biomed Anal 1989; 7:1617-22.
  • Singh AK, Jang Y, Mishra U, Granley K. Simultane- ous analysis of flunixin, naproxen, ethacrynic acid, in- domethacin, phenylbutazone, mefenamic acid and thi- osalicylic acid in plasma and urine by high-performance liquid chromatography and gas chromatography-mass spectrometry. J Chromatogr 1991; 568:351-61.
  • Jaussaud P, Guieu D, Courtot D, Barbier B. Identification of a tolfenamic acid metabolite in the horse by gas chro- matography-mass spectrometry. J Chromatogr 1992; 573:136-40.
  • Laakkonen UM, Leinonen A, Savonen L. Screening of non-steroidal anti-inflammatory drugs, barbiturates and methyl xanthines in equine urine by gas chromatogra- phy-mass spectrometry. Analyst 1994; 119:2695-96.
  • Delbeke FT, Debackere M. A liquid chromatographic method for the determination of fenoprofen in equine plasma and urine. Biomed Chromatogr 1994; 8:29-31.
  • Delbeke FT, Landuyt J, Debackere M. Disposition of hu- man drug preparations in the horse. IV. Orally adminis- tered fenoprofen. J Pharm Biomed Anal 1995; 13:1041-47.
  • González G, Ventura R, Smith AK, de la Torre R, Segura J. Detection of non-steroidal anti-inflammatory drugs in equine plasma and urine by gas chromatography-mass spectrometry. J Chromatogr A 1996; 719:251-64.
  • Tsitsimpikou C, Spyridaki MHE, Georgoulakis I, Koure- tas D, Konstantinidou M, Georgakopoulos CG. Elimina- tion profiles of flurbiprofen and its metabolites in equine urine doping analysis. Talanta 2001; 55:1173-80.
  • Kim JY, Kim SJ, Paeng KJ, Chung BC. Measurement of ke- toprofen in horse urine using gas chromatography-mass spectrometry. J Vet Pharmacol Therap 2001; 24:315-19.
  • Kvaternick V, Malinski T, Wortmann J, Fischer J. Quan- titative HPLC-UV method for the determination of firo- coxib from horse and dog plasma. J Chromatogr B 2007; 854:313-19.
  • Wynne PM, Batty DC, Vine JH, Simpson NJK. Ap- proaches to the solid-phase extraction of equine urine. Chromatographia 2004; 59–Suppl.: 51-60.
  • Spyridaki MHE, Lyris E, Georgoulakis I, Kouretas D, Konstantinidou M, Georgakopoulos CG. Determination of xylazine and its metabolites by GC-MS in equine urine for doping analysis. J Pharm Biomed Anal 2004; 35:107-16.
  • Leung GNW, Chung EW, Ho ENM, Kwok WH, Leung DKK, Tang FPW, Wan TSM, Yu NH. High-throughput screening of corticosteroids and basic drugs in horse urine by liquid chromatography-tandem mass spec- trometry. J Chromatogr B 2005; 825:47-56.
  • Machnik M, Due M, Parr M, von Kuk C, Schanzer W. Case study: Doping substances in equestrian food sup- plements. Chromatographia 2004; 59: 131-35.
  • Leung GNW, Leung DKK, Wan TSM, Wong CHF. High- throughput screening sub-ppb levels of basic drugs in equine plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr A 2007; 1156:271-79.
  • Cárdenas S, Gallego M, Valcárcel M, Ventura R, Segura J. A partially automated pretreatment module for routine analyses for seventeen non-steroid antiinflammatory drugs in race horses using gas chromatography/mass spectrometry. Anal Chem 1996; 68:118-23.
  • Vonaparti A, Lyris E, Panderi I, Koupparis M, Georga- kopoulos C. Direct injection horse urine analysis for the quantification and identification of treshold substances for doping control.III. Determination of salicylic acid by liquid chromatography/quadrupole time-of-flight mass spectrometry. Anal Bioanal Chem 2009; 395:1403-10.
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There are 83 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Esra Tatar

Sibel Topçu This is me

İlkay Küçükgüzel This is me

Publication Date March 7, 2014
Published in Issue Year 2012 Volume: 16 Issue: 2

Cite

APA Tatar, E., Topçu, S., & Küçükgüzel, İ. (2014). Yarış atlarında kullanımı suistimal edilen bazı non-steroidal antienflamatuvar ilaçların biyolojik örneklerden kromatografik yöntemlerle miktar tayini. Marmara Pharmaceutical Journal, 16(2), 91-106. https://doi.org/10.12991/mpj.22953
AMA Tatar E, Topçu S, Küçükgüzel İ. Yarış atlarında kullanımı suistimal edilen bazı non-steroidal antienflamatuvar ilaçların biyolojik örneklerden kromatografik yöntemlerle miktar tayini. Marmara Pharm J. March 2014;16(2):91-106. doi:10.12991/mpj.22953
Chicago Tatar, Esra, Sibel Topçu, and İlkay Küçükgüzel. “Yarış atlarında kullanımı Suistimal Edilen Bazı Non-Steroidal Antienflamatuvar ilaçların Biyolojik örneklerden Kromatografik yöntemlerle Miktar Tayini”. Marmara Pharmaceutical Journal 16, no. 2 (March 2014): 91-106. https://doi.org/10.12991/mpj.22953.
EndNote Tatar E, Topçu S, Küçükgüzel İ (March 1, 2014) Yarış atlarında kullanımı suistimal edilen bazı non-steroidal antienflamatuvar ilaçların biyolojik örneklerden kromatografik yöntemlerle miktar tayini. Marmara Pharmaceutical Journal 16 2 91–106.
IEEE E. Tatar, S. Topçu, and İ. Küçükgüzel, “Yarış atlarında kullanımı suistimal edilen bazı non-steroidal antienflamatuvar ilaçların biyolojik örneklerden kromatografik yöntemlerle miktar tayini”, Marmara Pharm J, vol. 16, no. 2, pp. 91–106, 2014, doi: 10.12991/mpj.22953.
ISNAD Tatar, Esra et al. “Yarış atlarında kullanımı Suistimal Edilen Bazı Non-Steroidal Antienflamatuvar ilaçların Biyolojik örneklerden Kromatografik yöntemlerle Miktar Tayini”. Marmara Pharmaceutical Journal 16/2 (March 2014), 91-106. https://doi.org/10.12991/mpj.22953.
JAMA Tatar E, Topçu S, Küçükgüzel İ. Yarış atlarında kullanımı suistimal edilen bazı non-steroidal antienflamatuvar ilaçların biyolojik örneklerden kromatografik yöntemlerle miktar tayini. Marmara Pharm J. 2014;16:91–106.
MLA Tatar, Esra et al. “Yarış atlarında kullanımı Suistimal Edilen Bazı Non-Steroidal Antienflamatuvar ilaçların Biyolojik örneklerden Kromatografik yöntemlerle Miktar Tayini”. Marmara Pharmaceutical Journal, vol. 16, no. 2, 2014, pp. 91-106, doi:10.12991/mpj.22953.
Vancouver Tatar E, Topçu S, Küçükgüzel İ. Yarış atlarında kullanımı suistimal edilen bazı non-steroidal antienflamatuvar ilaçların biyolojik örneklerden kromatografik yöntemlerle miktar tayini. Marmara Pharm J. 2014;16(2):91-106.