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Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae

Year 2023, Volume: 12 Issue: 1, 39 - 50, 22.03.2023
https://doi.org/10.33714/masteb.1220668

Abstract

The synthesis of nanoparticles and the usage areas of these nanoparticles show a rapid increase. In addition to the beneficial use of nanoparticles, their toxic effects cannot be ignored. In our study, iron oxide nanoparticle (Fe@AV NPs) (mean size: 20.852 nm) was synthesized from Aloe vera plant and the developmental toxicity of zebrafish was investigated. Zebrafish embryo-larvae were treated with different concentrations of Fe@AV NPs (1, 10, and 50 mg/L) starting at 4 hours after fertilization and continuing until 96 hours, and different developmental parameters (such as survival rate, hatchability rates, malformations, and behavior) were examined. In our study, it was determined that Fe@AV NPs caused developmental toxicity in zebrafish embryos depending on the dose increase. More than 60% died at 96 hours, especially in the highest (50 mg/L) application group. It was observed that Fe@AV NPs decreased and delayed the success of exiting the chorion depending on the dose increase, and caused various morphological abnormalities (like pericardial edema, tail deformation, and scoliosis) in all application groups except the lowest application group (1 mg/L). While 10 mg/L Fe@AV NPs caused sleep-like behaviors during the daytime by decreasing the daytime motility of the larvae, it caused hyperactivity by increasing their nocturnal motility. The results of thigmotaxis, which is an anxiety parameter, were found to increase anxiety at 10 mg/L Fe@AV NPs exposure.Our findings showed that Fe@AV NPs synthesized from Aloe vera plant have in vivo toxicity and their use at concentrations lower than 1 mg/L can be safe in environmental and medical applications.

Thanks

We would like to thank Atatürk University Fisheries Faculty Aquatic Biotechnology Laboratory for providing the opportunity to experiment with zebrafish embryos and larvae in this study.

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Year 2023, Volume: 12 Issue: 1, 39 - 50, 22.03.2023
https://doi.org/10.33714/masteb.1220668

Abstract

References

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There are 68 citations in total.

Details

Primary Language English
Subjects Ecology
Journal Section Research Article
Authors

Mine Köktürk 0000-0003-4722-256X

Aybek Yiğit 0000-0001-8279-5908

Ekrem Sulukan 0000-0002-4414-9873

Publication Date March 22, 2023
Submission Date December 18, 2022
Acceptance Date January 16, 2023
Published in Issue Year 2023 Volume: 12 Issue: 1

Cite

APA Köktürk, M., Yiğit, A., & Sulukan, E. (2023). Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae. Marine Science and Technology Bulletin, 12(1), 39-50. https://doi.org/10.33714/masteb.1220668
AMA Köktürk M, Yiğit A, Sulukan E. Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae. Mar. Sci. Tech. Bull. March 2023;12(1):39-50. doi:10.33714/masteb.1220668
Chicago Köktürk, Mine, Aybek Yiğit, and Ekrem Sulukan. “Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae”. Marine Science and Technology Bulletin 12, no. 1 (March 2023): 39-50. https://doi.org/10.33714/masteb.1220668.
EndNote Köktürk M, Yiğit A, Sulukan E (March 1, 2023) Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae. Marine Science and Technology Bulletin 12 1 39–50.
IEEE M. Köktürk, A. Yiğit, and E. Sulukan, “Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae”, Mar. Sci. Tech. Bull., vol. 12, no. 1, pp. 39–50, 2023, doi: 10.33714/masteb.1220668.
ISNAD Köktürk, Mine et al. “Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae”. Marine Science and Technology Bulletin 12/1 (March 2023), 39-50. https://doi.org/10.33714/masteb.1220668.
JAMA Köktürk M, Yiğit A, Sulukan E. Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae. Mar. Sci. Tech. Bull. 2023;12:39–50.
MLA Köktürk, Mine et al. “Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae”. Marine Science and Technology Bulletin, vol. 12, no. 1, 2023, pp. 39-50, doi:10.33714/masteb.1220668.
Vancouver Köktürk M, Yiğit A, Sulukan E. Green Synthesis Iron Oxide Nanoparticles (Fe@AV NPs) Induce Developmental Toxicity and Anxiety-Like Behavior in Zebrafish Embryo-Larvae. Mar. Sci. Tech. Bull. 2023;12(1):39-50.

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