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Glutatyon S-transferaz enzimleri polimorfizminin küçük hücreli akciğer kanserindeki rolü

Year 2022, , 513 - 517, 30.12.2022
https://doi.org/10.18663/tjcl.1125416

Abstract

Amaç: Bu çalışmada, KHAK (Küçük hücreli akciğer kanseri) gelişmesinde glutatyon S-transferaz (GST); GSTM1, GSTT1 ve GSTP1) polimorfizmlerinin rolünü Türk popülasyonunda araştırmayı amaçladık. Çalışmada, GST geninin üç farklı genetik varyantı için akciğer kanserine duyarlılığı değiştirmedeki rolünü değerlendirdik.
Gereç ve Yöntem: Çalışmaya Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesinde KHAK tanısı konulan 28 hasta dahil edildi ve çalışma lokal etik komitesi tarafından onaylandı. GST polimorfizmleri, hastalardan alınan kan örneklerinde çalışıldı.
Bulgular: Küçük hücreli akciğer kanseri tanısı almış hastalarda, GST’nin M1, T1 ve P1 alt gruplarındaki pozitiflik oranları arasında anlamlı farklılık bulunmuştur.
Sonuç: GSTM1 genotipi taşıyan bireylerde akciğer kanseri riskinin arttığı söylenebilir.

References

  • 1. World Health Organization. International Agency For Research On Cancer. 2020; Erişim tarihi: 05/03/2021, https://gco.iarc.fr/today/data/factsheets/cancers/15-Lung-fact-sheet.pdf
  • 2. World Health Organization. International Agency for Research on Cancer. 2020; Erişim tarihi: 05/03/2021, https://gco.iarc.fr/today/online-analysis
  • 3. American Joint Commitee on Cancer (AJCC) Cancer Staging Manual 5th ed. Philadelphia Lippincort-Raven; 1997. p. 127- 37.
  • 4. Oyama T, Sugio K, Isse T, et al. Expression of cytochrome P450 in non-small cell lung cancer. Front Bio Sci 2008; 13: 5787-93.
  • 5. Yavşan DM, Pamuk G, Eren RM, Teke T, Maden E, Uzun K. Micronodular metastasis in lung cancer. J Chest Diseases Critical Care 2014; 1: 35-40.
  • 6. Skarin AT, Herbst RS, Leong TL, Bailey A, Sugarbaker D. Lung cancer in patients under age 40. Lung Cancer 2001; 32: 255-64.
  • 7. Ada AO, C Kunak S, Hancer F, et al. CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients. Neoplasma 2010; 57: 512-21.
  • 8. Bartsch H, Castegnaro M, Rojas M, et al. Expression of pulmonary cytochrome P4501A1 and carcinogen DNA adduct formation in high risk subjects for tobacco-related lung cancer. Tox Lett 1992; 64-65: 477–483.
  • 9. Strange RC, Spiteri MA, Ramachandran S, Fryer AA Glutathione S-transferase family of enzymes. Mutation Res 2001; 482: 21–6.
  • 10. Eaton DL, Bammler TK. Concise review of glutathione S- transferase and their significance to toxicology. Toxicological Sciences 1999; 49: 156-64.
  • 11. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005; 45: 51-88.
  • 12. Ada AO, Kunak SC, Hancer F, et al. Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population. Mol Biol Rep 2012; 39: 5985-93.
  • 13. Di Pietro G, Magno LA, Rios-Santos F. Glutathione S-transferases: an overview in cancer research. Expert Opin Drug Metab Toxicol 2010; 6: 153-70.
Year 2022, , 513 - 517, 30.12.2022
https://doi.org/10.18663/tjcl.1125416

Abstract

References

  • 1. World Health Organization. International Agency For Research On Cancer. 2020; Erişim tarihi: 05/03/2021, https://gco.iarc.fr/today/data/factsheets/cancers/15-Lung-fact-sheet.pdf
  • 2. World Health Organization. International Agency for Research on Cancer. 2020; Erişim tarihi: 05/03/2021, https://gco.iarc.fr/today/online-analysis
  • 3. American Joint Commitee on Cancer (AJCC) Cancer Staging Manual 5th ed. Philadelphia Lippincort-Raven; 1997. p. 127- 37.
  • 4. Oyama T, Sugio K, Isse T, et al. Expression of cytochrome P450 in non-small cell lung cancer. Front Bio Sci 2008; 13: 5787-93.
  • 5. Yavşan DM, Pamuk G, Eren RM, Teke T, Maden E, Uzun K. Micronodular metastasis in lung cancer. J Chest Diseases Critical Care 2014; 1: 35-40.
  • 6. Skarin AT, Herbst RS, Leong TL, Bailey A, Sugarbaker D. Lung cancer in patients under age 40. Lung Cancer 2001; 32: 255-64.
  • 7. Ada AO, C Kunak S, Hancer F, et al. CYP and GST polymorphisms and survival in advanced non-small cell lung cancer patients. Neoplasma 2010; 57: 512-21.
  • 8. Bartsch H, Castegnaro M, Rojas M, et al. Expression of pulmonary cytochrome P4501A1 and carcinogen DNA adduct formation in high risk subjects for tobacco-related lung cancer. Tox Lett 1992; 64-65: 477–483.
  • 9. Strange RC, Spiteri MA, Ramachandran S, Fryer AA Glutathione S-transferase family of enzymes. Mutation Res 2001; 482: 21–6.
  • 10. Eaton DL, Bammler TK. Concise review of glutathione S- transferase and their significance to toxicology. Toxicological Sciences 1999; 49: 156-64.
  • 11. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005; 45: 51-88.
  • 12. Ada AO, Kunak SC, Hancer F, et al. Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population. Mol Biol Rep 2012; 39: 5985-93.
  • 13. Di Pietro G, Magno LA, Rios-Santos F. Glutathione S-transferases: an overview in cancer research. Expert Opin Drug Metab Toxicol 2010; 6: 153-70.
There are 13 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Semih Kunak

Publication Date December 30, 2022
Published in Issue Year 2022

Cite

APA Kunak, S. (2022). Glutatyon S-transferaz enzimleri polimorfizminin küçük hücreli akciğer kanserindeki rolü. Turkish Journal of Clinics and Laboratory, 13(4), 513-517. https://doi.org/10.18663/tjcl.1125416
AMA Kunak S. Glutatyon S-transferaz enzimleri polimorfizminin küçük hücreli akciğer kanserindeki rolü. TJCL. December 2022;13(4):513-517. doi:10.18663/tjcl.1125416
Chicago Kunak, Semih. “Glutatyon S-Transferaz Enzimleri Polimorfizminin küçük hücreli akciğer kanserindeki rolü”. Turkish Journal of Clinics and Laboratory 13, no. 4 (December 2022): 513-17. https://doi.org/10.18663/tjcl.1125416.
EndNote Kunak S (December 1, 2022) Glutatyon S-transferaz enzimleri polimorfizminin küçük hücreli akciğer kanserindeki rolü. Turkish Journal of Clinics and Laboratory 13 4 513–517.
IEEE S. Kunak, “Glutatyon S-transferaz enzimleri polimorfizminin küçük hücreli akciğer kanserindeki rolü”, TJCL, vol. 13, no. 4, pp. 513–517, 2022, doi: 10.18663/tjcl.1125416.
ISNAD Kunak, Semih. “Glutatyon S-Transferaz Enzimleri Polimorfizminin küçük hücreli akciğer kanserindeki rolü”. Turkish Journal of Clinics and Laboratory 13/4 (December 2022), 513-517. https://doi.org/10.18663/tjcl.1125416.
JAMA Kunak S. Glutatyon S-transferaz enzimleri polimorfizminin küçük hücreli akciğer kanserindeki rolü. TJCL. 2022;13:513–517.
MLA Kunak, Semih. “Glutatyon S-Transferaz Enzimleri Polimorfizminin küçük hücreli akciğer kanserindeki rolü”. Turkish Journal of Clinics and Laboratory, vol. 13, no. 4, 2022, pp. 513-7, doi:10.18663/tjcl.1125416.
Vancouver Kunak S. Glutatyon S-transferaz enzimleri polimorfizminin küçük hücreli akciğer kanserindeki rolü. TJCL. 2022;13(4):513-7.


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