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Bölgesel nöral tüp defektli gebelerin sağlıklı gebelerle karşılaştırılması

Year 2018, , 50 - 54, 20.03.2018
https://doi.org/10.18663/tjcl.391392

Abstract

Amaç:
Nöral
tüp defektleri  nöral tüpün bir bölümünün
kapanmasında meydana gelen kusur sonucu ortaya çıkan ve sık görülen
konjenital  anomalilerdir. Dünya çapında her yıl yaklaşık 300.000 bebek NTD ile
doğmaktadır ve NTD konjenital anomalilerle ilişkili neonatal ölümlerin yaklaşık
olarak %29’undan sorumlu tutulmaktadır. Bu çalışmada Kırıkkale ilinde 2014-2017
yılları arasında saptanan NTD’li gebeler ile sağlıklı gebelerin demografik
özellikleri ve laboratuar bulgularını karşılaştırmayı amaçladık.



Gereç ve Yöntem: Bu
retrospektif çalışmaya NTD’i tanısı almış 27 olgu ve  30 sağlıklı gebe dahil edildi. Olguların
demografik verileri ve laboratuvar değerleri kayıtlardan tarandı ve kaydedildi.
Bulgular NTD’li ve sağlıklı gebelik grupları arasında karşılaştırıldı.



Bulgular: NTD’li hastaların 15
tanesi meningomyelosel, 4 tanesi anensefali, 2 tanesi ensefalosel, 2 tanesi
eksensefali, 2 tanesi
anensefali+ensefalosel, 1 tanesi
meningomyelosel+ensefalosel ve 1 tanesi de myeloşizis
tanılı idi. NTD grubunun ortalama vücut kitle indeksi kontrol grubuna göre
anlamlı olarak yüksekti. Gruplar arasında laboratuvar parametreleri açısından
istatistiksel olarak anlamlı bir fark yoktu.



Sonuçlar: Kırıkkale ilinde NTD’li ve
sağlıklı gebeleri karşılaştırdığımız çalışmamızda NTD grubunda VKİ’nin kontrol
grubuna göre anlamlı daha yüksek olduğunu tespit ettik. Çok merkezli ve artmış
popülasyonla yapılacak yeni çalışmalar, Türk toplumunda NTD risklerini
ayrıntılı olarak belirlemek açısından faydalı olacaktır.

References

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  • 2. American College of Obstetrics and Gynecology. ACOG (American College of Obstetrics and Gynecology) Practice Bulletin: Neural tube defects. Obstet Gynecol 2017; 130: 6
  • 3. Moretti ME, Bar-Oz B, Fried S, Koren G. Maternal hyperthermia and the risk for neural tube defects in offspring: systematic review and meta-analysis. Epidemiol 2005; 16: 216-9.
  • 4. Zaganjor I, Sekkarie A, Tsang BL et al. Describing the prevalence of neural tube defects worldwide: a systematic literature review. PLoS One 2016; 11: 11.
  • 5. Christianson A, Howson CP, Modell B. March of Dimesglobal report on birth defects: the hidden toll of dying anddisabled children. White Plains (NY): March of Dimes Birth Defects Foundation 2006; 12.
  • 6. Mitchell LE. Epidemiology of neural tube defects. Am J Med Genet C Semin Med Genet 2005; 135: 88-94.
  • 7. Grewal J, Carmichael SL, Song J, Shaw GM. Neural tube defects: an analysis of neighbourhood and individual-level socio-economic characteristics. Paediatr Perinat Epidemiol 2009; 23: 116-24.
  • 8. Bowman RM, McLone DG, Grant JA, Tomita T, Ito JA. Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg 2001; 34: 114-20.
  • 9. Yi Y, Lindemann M, Colligs A, Snowball C. Economic burden of neural tube defects and impact of prevention with folic acid: a literature review. Eur J Pediatr 2011; 170:1391-400.
  • 10. Frey L, Hauser WA. Epidemiology of neural tube defects. Epilepsia 2003; 44: 4-13.
  • 11. Unusan N. Assesment of Turkish women’s knowledge concerning folic acid and prevention of birth defects. Public Health Nutrition 2004; 7: 851-5.
  • 12. Materna-Kiryluk A, Wiśniewska K, Badura-Stronka M, et al. Parental age as a risk factor for isolated congenital malformations in a Polish population. Paediatr Perinat Epidemiol 2009; 23: 29-40.
  • 13. Yavuzcan A, Topuz S, Çağlar M, Dilbaz S, Üstün Y, Kumru S. Düzce ilinde nöral tüp defekti saptanan olguların değerlendirilmesi. JOPP Derg 2013; 5: 125-30.
  • 14. Stothard KJ, Tennant PW, Bell R, Rankin J. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 2009; 301: 636–50.
  • 15. Rasmussen SA, Chu SY, Kim SY, Schmid CH, Lau J. Maternal obesity and risk of neural tube defects: a meta-analysis. Am J Obstet Gynecol 2008; 198: 611-9.
  • 16. Liu J, Li Z, Greene NDE, Li H, Ren A. The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China. Oncotarget 2017; 8: 72577-83.
  • 17. Nussbaum RL, McInnes RR, Willard HF. Complex inheritance of common multifactorial disorders. In: Thompson & Thompson genetics in medicine. 8th ed. Philadelphia (PA): Elsevier; 2016; 133-53.
  • 18. Bonaiti-Pellie C, Smith C. Risk tables for genetic counselling in some common congenital malformations. J Med Genet 1974; 11: 374-7.
  • 19. Dreier JW, Andersen AM, Berg-Beckhoff G. Systematic review and meta-analyses: fever in pregnancy and health impacts in the offspring. Pediatrics 2014; 133: 674-88.
  • 20. Duong HT, Shahrukh Hashmi S, Ramadhani T, et al. Maternal use of hot tub and major structural birth defects. Birth Defects Res A Clin Mol Teratol 2011; 91: 836-41.
  • 21. Smithells RW, Sheppard S, Schorah CJ. Vitamin deficiencies and neural tube defects. Arch Dis Child 1976; 51: 944–50.
  • 22. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338: 131-7.
  • 23. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327: 1832–5.
  • 24. Wilson RD, Wilson RD, Audibert F, et al. Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies. Genetics Committee. J Obstet Gynaecol Can 2015; 37: 534-52.
  • 25. Zhang X, Li S, Wu S, et al. Prevalence of birth defects and risk-factor analysis from a population based survey in Inner Mongolia, China. BMC Pediatr 2012; 12: 125.
  • 26. Wu Y, Wang F, Fu M, Wang C, Quon MJ, Yang P. Cellular stress, excessive apoptosis, and the effect of metformin in a mouse model of type 2 diabetic embryopathy. Diabetes 2015; 64: 2526-36.
  • 27. Lupo PJ, Canfield MA, Chapa C, et al. Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study. Am J Epidemiol 2012;1 76: 1101-9.
  • 28. Ceyhan ST, Beyan C, Atay V, et al. Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect. Gynecol Endocrinol 2010; 26: 578-81.
Year 2018, , 50 - 54, 20.03.2018
https://doi.org/10.18663/tjcl.391392

Abstract

References

  • 1. Giordan E, Bortolotti C, Lanzino G, Brinjikji W. Spinal arteriovenous vascular malformations in patients with neural tube defects. AJNR Am J Neuroradiol 2017; 28: 1
  • 2. American College of Obstetrics and Gynecology. ACOG (American College of Obstetrics and Gynecology) Practice Bulletin: Neural tube defects. Obstet Gynecol 2017; 130: 6
  • 3. Moretti ME, Bar-Oz B, Fried S, Koren G. Maternal hyperthermia and the risk for neural tube defects in offspring: systematic review and meta-analysis. Epidemiol 2005; 16: 216-9.
  • 4. Zaganjor I, Sekkarie A, Tsang BL et al. Describing the prevalence of neural tube defects worldwide: a systematic literature review. PLoS One 2016; 11: 11.
  • 5. Christianson A, Howson CP, Modell B. March of Dimesglobal report on birth defects: the hidden toll of dying anddisabled children. White Plains (NY): March of Dimes Birth Defects Foundation 2006; 12.
  • 6. Mitchell LE. Epidemiology of neural tube defects. Am J Med Genet C Semin Med Genet 2005; 135: 88-94.
  • 7. Grewal J, Carmichael SL, Song J, Shaw GM. Neural tube defects: an analysis of neighbourhood and individual-level socio-economic characteristics. Paediatr Perinat Epidemiol 2009; 23: 116-24.
  • 8. Bowman RM, McLone DG, Grant JA, Tomita T, Ito JA. Spina bifida outcome: a 25-year prospective. Pediatr Neurosurg 2001; 34: 114-20.
  • 9. Yi Y, Lindemann M, Colligs A, Snowball C. Economic burden of neural tube defects and impact of prevention with folic acid: a literature review. Eur J Pediatr 2011; 170:1391-400.
  • 10. Frey L, Hauser WA. Epidemiology of neural tube defects. Epilepsia 2003; 44: 4-13.
  • 11. Unusan N. Assesment of Turkish women’s knowledge concerning folic acid and prevention of birth defects. Public Health Nutrition 2004; 7: 851-5.
  • 12. Materna-Kiryluk A, Wiśniewska K, Badura-Stronka M, et al. Parental age as a risk factor for isolated congenital malformations in a Polish population. Paediatr Perinat Epidemiol 2009; 23: 29-40.
  • 13. Yavuzcan A, Topuz S, Çağlar M, Dilbaz S, Üstün Y, Kumru S. Düzce ilinde nöral tüp defekti saptanan olguların değerlendirilmesi. JOPP Derg 2013; 5: 125-30.
  • 14. Stothard KJ, Tennant PW, Bell R, Rankin J. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 2009; 301: 636–50.
  • 15. Rasmussen SA, Chu SY, Kim SY, Schmid CH, Lau J. Maternal obesity and risk of neural tube defects: a meta-analysis. Am J Obstet Gynecol 2008; 198: 611-9.
  • 16. Liu J, Li Z, Greene NDE, Li H, Ren A. The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China. Oncotarget 2017; 8: 72577-83.
  • 17. Nussbaum RL, McInnes RR, Willard HF. Complex inheritance of common multifactorial disorders. In: Thompson & Thompson genetics in medicine. 8th ed. Philadelphia (PA): Elsevier; 2016; 133-53.
  • 18. Bonaiti-Pellie C, Smith C. Risk tables for genetic counselling in some common congenital malformations. J Med Genet 1974; 11: 374-7.
  • 19. Dreier JW, Andersen AM, Berg-Beckhoff G. Systematic review and meta-analyses: fever in pregnancy and health impacts in the offspring. Pediatrics 2014; 133: 674-88.
  • 20. Duong HT, Shahrukh Hashmi S, Ramadhani T, et al. Maternal use of hot tub and major structural birth defects. Birth Defects Res A Clin Mol Teratol 2011; 91: 836-41.
  • 21. Smithells RW, Sheppard S, Schorah CJ. Vitamin deficiencies and neural tube defects. Arch Dis Child 1976; 51: 944–50.
  • 22. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991; 338: 131-7.
  • 23. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327: 1832–5.
  • 24. Wilson RD, Wilson RD, Audibert F, et al. Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies. Genetics Committee. J Obstet Gynaecol Can 2015; 37: 534-52.
  • 25. Zhang X, Li S, Wu S, et al. Prevalence of birth defects and risk-factor analysis from a population based survey in Inner Mongolia, China. BMC Pediatr 2012; 12: 125.
  • 26. Wu Y, Wang F, Fu M, Wang C, Quon MJ, Yang P. Cellular stress, excessive apoptosis, and the effect of metformin in a mouse model of type 2 diabetic embryopathy. Diabetes 2015; 64: 2526-36.
  • 27. Lupo PJ, Canfield MA, Chapa C, et al. Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study. Am J Epidemiol 2012;1 76: 1101-9.
  • 28. Ceyhan ST, Beyan C, Atay V, et al. Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect. Gynecol Endocrinol 2010; 26: 578-81.
There are 28 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Cemile Dayangan Sayan

Nevin Sağsöz

Zehra Sema Özkan

Mahmut İlkin Yeral

Serkan Tursun

Publication Date March 20, 2018
Published in Issue Year 2018

Cite

APA Dayangan Sayan, C., Sağsöz, N., Özkan, Z. S., Yeral, M. İ., et al. (2018). Bölgesel nöral tüp defektli gebelerin sağlıklı gebelerle karşılaştırılması. Turkish Journal of Clinics and Laboratory, 9(1), 50-54. https://doi.org/10.18663/tjcl.391392
AMA Dayangan Sayan C, Sağsöz N, Özkan ZS, Yeral Mİ, Tursun S. Bölgesel nöral tüp defektli gebelerin sağlıklı gebelerle karşılaştırılması. TJCL. March 2018;9(1):50-54. doi:10.18663/tjcl.391392
Chicago Dayangan Sayan, Cemile, Nevin Sağsöz, Zehra Sema Özkan, Mahmut İlkin Yeral, and Serkan Tursun. “Bölgesel nöral tüp Defektli Gebelerin sağlıklı Gebelerle karşılaştırılması”. Turkish Journal of Clinics and Laboratory 9, no. 1 (March 2018): 50-54. https://doi.org/10.18663/tjcl.391392.
EndNote Dayangan Sayan C, Sağsöz N, Özkan ZS, Yeral Mİ, Tursun S (March 1, 2018) Bölgesel nöral tüp defektli gebelerin sağlıklı gebelerle karşılaştırılması. Turkish Journal of Clinics and Laboratory 9 1 50–54.
IEEE C. Dayangan Sayan, N. Sağsöz, Z. S. Özkan, M. İ. Yeral, and S. Tursun, “Bölgesel nöral tüp defektli gebelerin sağlıklı gebelerle karşılaştırılması”, TJCL, vol. 9, no. 1, pp. 50–54, 2018, doi: 10.18663/tjcl.391392.
ISNAD Dayangan Sayan, Cemile et al. “Bölgesel nöral tüp Defektli Gebelerin sağlıklı Gebelerle karşılaştırılması”. Turkish Journal of Clinics and Laboratory 9/1 (March 2018), 50-54. https://doi.org/10.18663/tjcl.391392.
JAMA Dayangan Sayan C, Sağsöz N, Özkan ZS, Yeral Mİ, Tursun S. Bölgesel nöral tüp defektli gebelerin sağlıklı gebelerle karşılaştırılması. TJCL. 2018;9:50–54.
MLA Dayangan Sayan, Cemile et al. “Bölgesel nöral tüp Defektli Gebelerin sağlıklı Gebelerle karşılaştırılması”. Turkish Journal of Clinics and Laboratory, vol. 9, no. 1, 2018, pp. 50-54, doi:10.18663/tjcl.391392.
Vancouver Dayangan Sayan C, Sağsöz N, Özkan ZS, Yeral Mİ, Tursun S. Bölgesel nöral tüp defektli gebelerin sağlıklı gebelerle karşılaştırılması. TJCL. 2018;9(1):50-4.


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