Koroner yavaş akımın ortalama trombosit nacmi/lenfosit oranı ile İlişkisi

Year 2018, , 210 - 215, 30.09.2018

Murat Gök Alparslan Kurtul

https://doi.org/10.18663/tjcl.447045

Abstract

Amaç: Bu çalışmanın amacı, kolayca hesaplanabilen yeni bir inflamatuar belirteç olan
ortalama trombosit hacmi/ lenfosit oranının koroner yavaş akım şiddeti ile
ilişkisini araştırmaktır.

Gereç ve Yöntemler: Kesitsel tipte yapılan bu çalışmada, Nisan 2016 ile
Nisan 2017 tarihleri arasında hastanemize başvuran toplam 166 hasta dahil
edilmiştir. Koroner yavaş akım grubuna 83 hasta, normal koroner akım grubuna 83
hasta dahil edildi. Tüm hastaların koroner akım hızları Timi Kare Sayımı (TIMI)
yöntemi ile hesaplanmıştır. Tüm verilerin analizi için SPSS 22.0 istatistiksel
paket programı kullanılmıştır.

Bulgular: Ortalama trombosit hacmi/ lenfosit oranı, koroner
yavaş akım grubunda normal koroner akım grubuna göre istatistiksel olarak daha
anlamlı bulundu. (p <0.001) Çok değişkenli lojistik regresyon analizinde,
ortalama trombosit hacmi/ lenfosit oranı koroner yavaş akımın bağımsız öngördürücüsü
olduğu bulundu. (p <0.001) Buna ek olarak, HsCRP, total kolesterol, HDL ile
koroner yavaş akım arasında pozitif bir korelasyon saptandı. (p <0.05)

Sonuç: Yeni ve basit bir inflamasyon göstergesi olan ortalama trombosit hacmi
/ lenfosit oranı, koroner yavaş akım saptanan hastalarda daha yüksek bulundu.
Bu yüksek oran, koroner yavaş akım saptanan hastaları takipte klinisyenler için
önemli bir gösterge niteliği taşıyor olabilir.

Keywords

inflamasyon, lenfosit, ortalama trombosit hacmi, yavaş akım

Relationship between coronary slow flow and mean platelet volume / lymphocyte ratio

Abstract

Aim: The aim of this study was to investigate the
association of the mean platelet volume to lymphocyte ratio, a novel inflammatory marker that is easily calculated,
with coronary slow flow severity.

Material and Method: In this cross-sectional study, a total of 166 patients
referred to our hospital between April 2016 and April 2017 were included. 83
patients were included in the coronary slow flow group, and 83 patients were
included in the normal coronary flow group. Coronary
flow velocities of all patients were measured by the Timi Frame Count (TIMI)
method. SPSS 22.0 statistical package program
was used for analysis of all data.

Results: MPVLR was statistically more significant in coronary
slow flow group compared to normal coronary flow group.(p<0.001) In
multivariate regression analysis, MVPLR was found to be an independent
predictor of coronary slow flow.(p<0.001) In addition, there was a
positive correlation between HsCRP, total cholesterol, HDL and coronary slow
flow. (p<0.05)

Conclusion: Mean platelet volume to lymphocyte ratio, a new and
simple indicator of inflammation, was found to be higher in patients with
coronary slow flow. This high ratio may be indicative for clinicians following
patients with severe coronary slow flow.

Keywords

inflammation, lymphocyte, mean platelet volume, coronary slow fl

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