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The relationship between fibrinogen to albumin ratio and carotid artery disease in patients with carotid endarterectomy and patients with non severe carotid artery stenosis

Year 2018, , 321 - 326, 28.12.2018
https://doi.org/10.18663/tjcl.461635

Abstract

Aim: To investigate the relationship
between  fibrinogen to albumin ratio
(FAR) and carotid artery stenosis (CAS).

Material and Methods: This study
included patients who underwent carotid endarterctomy
(CEA) as CEA group and unoperated patients who have CAS  less than 50% as non-surgical group. CAS was
diagnosed with history and physical examination followed by doppler
ultrasonography and carotid angiography. All data retrieved retrospectively
from the hospital medical files. Hematologic parameters were measured and
recorded. In addition, FAR was calculated.

Results: Fifty patients were included
in CEA group (70.0 % male, mean age: 71.0 ± 7.7 years) and 60 patients were
invluded in non-surgical group (70.0 % male, mean age: 63.9 ± 8.0 years). In
logistic regression analysis advanced age, presence of coronary artery disease
and FAR were identified as an independent predictor of
the development of CAS
. In Receiver operating characteristic (ROC) curve
analysis, for predicting development of CAS, there were 68.0% sensitivity and
65.0% specificity for FAR (area under the curve [AUC]: 0.669, 95% CI:
0.566-0.771, log rank p = 0.002).







Conclusion: We found that FAR were
identified as an independent predictor of the development of CAS. FAR could be
a potential marker on carotid atherosclerosis in patients. But there is a need
large studies including all cardiovascular diseases.

References

  • 1. Boulos NM, Gardin JM, Malik S, Postley J, Wong ND. Carotid plaque characterization, stenosis, and intima-media thickness according to age and gender in a large registry cohort. Am J Cardio 2016; 117: 1185-91.
  • 2. Divya KP, Sandeep N, Sarma S, Sylaja PN. Risk of stroke and cardiac events in medically treated asymptomatic carotid stenosis. J Stroke Cerebrovasc Dis 2015; 24: 2149-53.
  • 3. Gresele P, Deckmyn H, Huybrechts E, Vermylen J. Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D2. Biochem Pharmaco. 1984; 33: 2083-88.
  • 4. Joles JA, Willekes-Koolschijn N, Koomans HA. Hypoalbuminemia causes high blood viscosity by increasing red cell lysophosphatidylcholine. Kidney Int 1997; 52: 761-70.
  • 5. Oduncu V, Erkol A, Karabay CY et al. The prognostic value of serum albumin levels on admission in patients with acute STsegment elevation myocardial infarction undergoing a primary percutaneous coronary intervention. Coron Artery Dis 2013; 24: 88-94.
  • 6. Pieters M, Kotze RC, Jerling JC, Kruger A, Ariëns RAS. Evidence that fibrinogen ý regulates plasma clot structure and lysis and relationship to cardiovascular risk factors in black Africans. Blood 2013; 121: 3254-60.
  • 7. Batagini1 NC, Silva ES, Pinto CAV, Puech-Leăo P, Luccia N. Analysis of risk factors and diseases associated with atherosclerosis in the progression of carotid artery stenosis. Vascular 2015; 24: 59-63
  • 8. Perl ML, Finkelstein A, Revivo M et al. Variance in Biomarker Usefulness as Indicators for Carotid and Coronary Atherosclerosis. IMAJ 2016; 18: 80–84.
  • 9. Zhang Y, Zhu CG, Guo YL et al. Higher fibrinogen level is independently linked with the presence and severity of new-onset coronary atherosclerosis among Han Chinese population. PLoS One 2014; 9: 113460.
  • 10. Van den Munckhof ICL, Jones H, Hopman MTE et al. Relation between age and carotid artery intima-medial thickness: a systematic review. Clin Cardiol 2018; 41: 698-704.
  • 11. Yokokawa H, Yasumura S, Tanno K et al. Serum low-density lipoprotein to high-density lipoprotein ratio as a predictor of future acute myocardial infarction among men in a 2.7-year cohort study of a Japanese northern rural population. J Atheroscler Thromb 2011; 18: 89-98.
  • 12. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 2002; 106: 3143-421
  • 13. Folsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE. Prospective study of hemostatic factors and incidence of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1997; 96: 1102-8.
  • 14. Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, Larsson B, Welin L,Tibblin G. Fibrinogen as risk factor for stroke and myocardial infarction.N Eng J Med 1984; 311: 501-5.
  • 15. Cho HM, Kang DR, Kim HC, Oh SM, Kim BK, Il Suh. Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population. Yonsei Med J 2015; 56: 921-927.
  • 16. Ishihara KK, Kokubo Y, Yokota C et al. Effect of Plasma Fibrinogen, High-Sensitive C-Reactive Protein, and Cigarette Smoking on Carotid Atherosclerosis: The Suita Study. Journal of Stroke and Cerebrovascular Diseases. J Stroke Cerebrovasc Dis. 2015; 24: 2385-89
  • 17. Xu O, Yan Y, Gu S et al. A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma. Journal of Immunology Research 2018; 1-11
  • 18. Seo MH, Choa M, You JS, et al. “Hypoalbuminemia, low base excess values, and tachypnea predict 28-day mortality in severe sepsis and septic shock patients in the emergency department,” Yonsei Medical Journal 2016: 57; 1361–69.
  • 19. Hwang KT, Chung JK, Roh EY, et al. Prognostic Influence of Preoperative Fibrinogen to Albumin Ratio for Breast Cancer. J Breast Cancer 2017; 20: 254-63.
  • 20. Li XH, Gu WS, Wang XP et al. Low Preoperative albumin-to-globulin ratio Predict Poor Survival and Negatively Correlated with Fibrinogen in Resectable Esophageal Squamous Cell Carcinoma. Journal of Cancer 2017; 8: 1833-42.
  • 21. Li SQ, Jiang YH, Lin J et al. Albumin-to- Fibrinogen ratio as a promising biomarker to predict clinical outcome of non-small cell lung cancer individuals. Cancer Medicine 2018; 7: 1221–31.
  • 22. Karahan O, Acet H, Ertaş F et al. The relationship between fibrinogen to albumin ratio and severity of coronary artery disease in patients with STEMI. Am J Emerg Med. 2016; 34: 1037-42.

Karotis endarterektomili ve şiddetli olmayan karotis arter darlığı olan hastalarda fibrinojen / albümin oranı ve karotis arter hastalığı arasındaki ilişki.

Year 2018, , 321 - 326, 28.12.2018
https://doi.org/10.18663/tjcl.461635

Abstract

Amaç: Fibrinojen ile albumin oranı (FAR)
ve karotis arter stenozu (KAS) arasındaki ilişkiyi araştırmak.

Gereç ve Yöntemler: Bu çalışma, karotis
endarterektomisi (KEA) geçiren hastaları ve % 50'den az karotis arter stenozu
olan hastaları içermektedir. KAS tanısı fizik muayene, tıbbi hikaye ve ardından
doppler ultrasonografi ve karotis anjiyografi ile konuldu. Tüm veriler hastane
tıbbi dosyalarından retrospektif olarak alındı. Laboratuvar kan sonuçları ve
kaydedildi ve  FAR hesaplandı.

Bulgular: Elli hasta KEA grubuna dahil
edildi (% 70 erkek, ortalama yaş: 71.0 ± 7.7 ) ve 60 hasta cerrahi olmayan
grubuna dahil edildi (% 70 erkek, ortalama yaş: 63.9 ± 8.0 ). Lojistik
regresyon analizinde ileri yaş, koroner arter hastalığı ve FAR varlığı KAS gelişiminin
bağımsız bir prediktörü olarak tanımlandı. Receiver operating characteristic
(ROC) eğrisisi analizinde, KAS gelişimini tahmin etmek için FAR için % 68.0
duyarlılık ve % 65.0 özgüllük vardı (Area Under the Curve [AUC]: 0.669, 95% CI:
0.566-0.771, log rank p = 0.002).







Sonuçlar: FAR'ın KAS gelişiminin
bağımsız bir öngörücüsü olarak tanımlandığını bulduk. FAR, hastalarda karotis
aterosklerozu üzerinde potansiyel bir belirteç olabilir. Ancak, tüm
kardiyovasküler hastalıkları içeren büyük çalışmalara ihtiyaç vardır.

References

  • 1. Boulos NM, Gardin JM, Malik S, Postley J, Wong ND. Carotid plaque characterization, stenosis, and intima-media thickness according to age and gender in a large registry cohort. Am J Cardio 2016; 117: 1185-91.
  • 2. Divya KP, Sandeep N, Sarma S, Sylaja PN. Risk of stroke and cardiac events in medically treated asymptomatic carotid stenosis. J Stroke Cerebrovasc Dis 2015; 24: 2149-53.
  • 3. Gresele P, Deckmyn H, Huybrechts E, Vermylen J. Serum albumin enhances the impairment of platelet aggregation with thromboxane synthase inhibition by increasing the formation of prostaglandin D2. Biochem Pharmaco. 1984; 33: 2083-88.
  • 4. Joles JA, Willekes-Koolschijn N, Koomans HA. Hypoalbuminemia causes high blood viscosity by increasing red cell lysophosphatidylcholine. Kidney Int 1997; 52: 761-70.
  • 5. Oduncu V, Erkol A, Karabay CY et al. The prognostic value of serum albumin levels on admission in patients with acute STsegment elevation myocardial infarction undergoing a primary percutaneous coronary intervention. Coron Artery Dis 2013; 24: 88-94.
  • 6. Pieters M, Kotze RC, Jerling JC, Kruger A, Ariëns RAS. Evidence that fibrinogen ý regulates plasma clot structure and lysis and relationship to cardiovascular risk factors in black Africans. Blood 2013; 121: 3254-60.
  • 7. Batagini1 NC, Silva ES, Pinto CAV, Puech-Leăo P, Luccia N. Analysis of risk factors and diseases associated with atherosclerosis in the progression of carotid artery stenosis. Vascular 2015; 24: 59-63
  • 8. Perl ML, Finkelstein A, Revivo M et al. Variance in Biomarker Usefulness as Indicators for Carotid and Coronary Atherosclerosis. IMAJ 2016; 18: 80–84.
  • 9. Zhang Y, Zhu CG, Guo YL et al. Higher fibrinogen level is independently linked with the presence and severity of new-onset coronary atherosclerosis among Han Chinese population. PLoS One 2014; 9: 113460.
  • 10. Van den Munckhof ICL, Jones H, Hopman MTE et al. Relation between age and carotid artery intima-medial thickness: a systematic review. Clin Cardiol 2018; 41: 698-704.
  • 11. Yokokawa H, Yasumura S, Tanno K et al. Serum low-density lipoprotein to high-density lipoprotein ratio as a predictor of future acute myocardial infarction among men in a 2.7-year cohort study of a Japanese northern rural population. J Atheroscler Thromb 2011; 18: 89-98.
  • 12. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation 2002; 106: 3143-421
  • 13. Folsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE. Prospective study of hemostatic factors and incidence of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1997; 96: 1102-8.
  • 14. Wilhelmsen L, Svardsudd K, Korsan-Bengtsen K, Larsson B, Welin L,Tibblin G. Fibrinogen as risk factor for stroke and myocardial infarction.N Eng J Med 1984; 311: 501-5.
  • 15. Cho HM, Kang DR, Kim HC, Oh SM, Kim BK, Il Suh. Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population. Yonsei Med J 2015; 56: 921-927.
  • 16. Ishihara KK, Kokubo Y, Yokota C et al. Effect of Plasma Fibrinogen, High-Sensitive C-Reactive Protein, and Cigarette Smoking on Carotid Atherosclerosis: The Suita Study. Journal of Stroke and Cerebrovascular Diseases. J Stroke Cerebrovasc Dis. 2015; 24: 2385-89
  • 17. Xu O, Yan Y, Gu S et al. A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma. Journal of Immunology Research 2018; 1-11
  • 18. Seo MH, Choa M, You JS, et al. “Hypoalbuminemia, low base excess values, and tachypnea predict 28-day mortality in severe sepsis and septic shock patients in the emergency department,” Yonsei Medical Journal 2016: 57; 1361–69.
  • 19. Hwang KT, Chung JK, Roh EY, et al. Prognostic Influence of Preoperative Fibrinogen to Albumin Ratio for Breast Cancer. J Breast Cancer 2017; 20: 254-63.
  • 20. Li XH, Gu WS, Wang XP et al. Low Preoperative albumin-to-globulin ratio Predict Poor Survival and Negatively Correlated with Fibrinogen in Resectable Esophageal Squamous Cell Carcinoma. Journal of Cancer 2017; 8: 1833-42.
  • 21. Li SQ, Jiang YH, Lin J et al. Albumin-to- Fibrinogen ratio as a promising biomarker to predict clinical outcome of non-small cell lung cancer individuals. Cancer Medicine 2018; 7: 1221–31.
  • 22. Karahan O, Acet H, Ertaş F et al. The relationship between fibrinogen to albumin ratio and severity of coronary artery disease in patients with STEMI. Am J Emerg Med. 2016; 34: 1037-42.
There are 22 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Kadir Kaan Özsin 0000-0001-5933-9322

Umut Serhat Sanrı

Faruk Toktaş

Şenol Yavuz

Publication Date December 28, 2018
Published in Issue Year 2018

Cite

APA Özsin, K. K., Sanrı, U. S., Toktaş, F., Yavuz, Ş. (2018). The relationship between fibrinogen to albumin ratio and carotid artery disease in patients with carotid endarterectomy and patients with non severe carotid artery stenosis. Turkish Journal of Clinics and Laboratory, 9(4), 321-326. https://doi.org/10.18663/tjcl.461635
AMA Özsin KK, Sanrı US, Toktaş F, Yavuz Ş. The relationship between fibrinogen to albumin ratio and carotid artery disease in patients with carotid endarterectomy and patients with non severe carotid artery stenosis. TJCL. December 2018;9(4):321-326. doi:10.18663/tjcl.461635
Chicago Özsin, Kadir Kaan, Umut Serhat Sanrı, Faruk Toktaş, and Şenol Yavuz. “The Relationship Between Fibrinogen to Albumin Ratio and Carotid Artery Disease in Patients With Carotid Endarterectomy and Patients With Non Severe Carotid Artery Stenosis”. Turkish Journal of Clinics and Laboratory 9, no. 4 (December 2018): 321-26. https://doi.org/10.18663/tjcl.461635.
EndNote Özsin KK, Sanrı US, Toktaş F, Yavuz Ş (December 1, 2018) The relationship between fibrinogen to albumin ratio and carotid artery disease in patients with carotid endarterectomy and patients with non severe carotid artery stenosis. Turkish Journal of Clinics and Laboratory 9 4 321–326.
IEEE K. K. Özsin, U. S. Sanrı, F. Toktaş, and Ş. Yavuz, “The relationship between fibrinogen to albumin ratio and carotid artery disease in patients with carotid endarterectomy and patients with non severe carotid artery stenosis”, TJCL, vol. 9, no. 4, pp. 321–326, 2018, doi: 10.18663/tjcl.461635.
ISNAD Özsin, Kadir Kaan et al. “The Relationship Between Fibrinogen to Albumin Ratio and Carotid Artery Disease in Patients With Carotid Endarterectomy and Patients With Non Severe Carotid Artery Stenosis”. Turkish Journal of Clinics and Laboratory 9/4 (December 2018), 321-326. https://doi.org/10.18663/tjcl.461635.
JAMA Özsin KK, Sanrı US, Toktaş F, Yavuz Ş. The relationship between fibrinogen to albumin ratio and carotid artery disease in patients with carotid endarterectomy and patients with non severe carotid artery stenosis. TJCL. 2018;9:321–326.
MLA Özsin, Kadir Kaan et al. “The Relationship Between Fibrinogen to Albumin Ratio and Carotid Artery Disease in Patients With Carotid Endarterectomy and Patients With Non Severe Carotid Artery Stenosis”. Turkish Journal of Clinics and Laboratory, vol. 9, no. 4, 2018, pp. 321-6, doi:10.18663/tjcl.461635.
Vancouver Özsin KK, Sanrı US, Toktaş F, Yavuz Ş. The relationship between fibrinogen to albumin ratio and carotid artery disease in patients with carotid endarterectomy and patients with non severe carotid artery stenosis. TJCL. 2018;9(4):321-6.


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