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Penicillin-resistant pneumococcal meningitis following a head trauma in a chronic alcoholic patient

Year 2018, , 357 - 360, 28.12.2018
https://doi.org/10.18663/tjcl.462004

Abstract

Chronic alcohol use may
suppress central nervous system infections or interfere with clinical
conditions such as alcohol withdrawal syndrome. Sensitivity to infectious
agents is increased in alcoholic patients due to the impaired immunological
response to microorganisms, malnutrition and vitamin deficiency. The most
common meningitis in these patients is Streptococcus pneumoniae. Penicillin
resistance in pneumococci, is a major source of concern in recent years all
over the world and in Turkey. In the treatment of pneumococcal infections,
which are highly resistant to penicillin, a combination of third-generation
cephalosporins (ceftriaxone, cefotaxime) and vancomycin is applied along with
dexamethasone therapy. If there is a delay in the diagnosis and treatment of
pneumococcal meningitis, the mortality rate is high. In this article, we
present a 40-year-old male patient with chronic alcohol use history who was
diagnosed with penicillin-resistant Streptococcus
pneumoniae
meningitis with delayed diagnosis and mortality which was
developed after a head trauma. 

References

  • 1. Edward N. Janoff and Daniel M. Musher. Streptococcus pneumoniae. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Updated Edition, 2015; 2310-2327.e5.
  • 2. Van Veen KE, Brouwer MC, van der Ende A, van de Beek D. Bacterial meningitis in alcoholic patients: A population-based prospective study. J Infect 2017; 74 : 352-57.
  • 3. Kim AC, Epstein ME, Goyal PG, Doan TL. Infections in Alcoholic Liver Disease. Clin Liver Dis 2012; 16: 783–803.
  • 4. Leelarasamee A, Dhiraputra C, Hunnangkul S. Severe pneumococcal infection at a Thai hospital. Int J Infect Dis 1999; 3: 147-52.
  • 5. Weisfelt M, de Gans J, van der Ende A, van de Beek D. Community-acquired bacterial meningitis in alcoholic patients. PLoS One 2010; 5: 9102.
  • 6. Verghese VP, Veeraraghavan B, Jayaraman R, Varghese R, Neeravi A, Jayaraman Y, Thomas K, Mehendale SM. Increasing incidence of penicillin- and cefotaxime-resistant Streptococcus pneumoniae causing meningitis in India: Time for revision of treatment guidelines? Indian J Med Microbiol 2017; 35: 228-36.
  • 7. Cherazard R, Epstein M, Doan TL, Salim T, Bharti S, Smith MA. Antimicrobial Resistant Streptococcus pneumoniae: Prevalence, Mechanisms, and Clinical Implications. Am J Ther 2017 ; 24: 361-69.
  • 8. Muley VA, Ghadage DP, Yadav GE, Bhore AV. Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance. J Lab Physicians 2017 ; 9: 31-35.
  • 9. Erdem H, Elaldi N, Öztoprak N et al. Mortality indicators in pneumococcal meningitis: therapeutic implications. Int J Infect Dis 2014 ; 19: 13-19.
  • 10. Bijlsma M, Matthijs C Brouwer, E et al. Community-acquired bacterial meningitis in adults in the Netherlands, 2006–14: a prospective cohort study. Lancet Infect Dis 2016; 16: 339–47.
  • 11. Hameed N, Tunkel AR. Treatment of drug-resistant pneumococcal meningitis. Curr Infect Dis Rep 2010 ; 12: 274-81.
  • 12. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 20thInformational Supplement, 2010, M100-S20. CLSI, Wayne, PA.
  • 13. Taşova Y, Saltoğlu N, Dündar İH. Çok ilaca dirençli pnömokokal menenjit: bir olgu sunumu.Flora Dergisi 1998; 3: 134-39.

Kronik alkol kullanımı olan bir hastada kafa travmasını takiben gelişen penisiline dirençli pnömokok menenjiti

Year 2018, , 357 - 360, 28.12.2018
https://doi.org/10.18663/tjcl.462004

Abstract

Kronik alkol kullanan
bireylerde santral sinir sistemi infeksiyonu bulguları baskılanabilir veya
alkol yoksunluk sendromu gibi klinik durumlarla karışabilir. Alkolik hastalarda
mikroorganizmalara karşı immun yanıtın etkilenmesi, malnutrisyon ve vitamin
eksikliği gibi nedenlerle infeksiyon etkenlerine karşı duyarlılık artar. Bu
hastalarda en sık görülen menenjit etkeni
Streptococcus
pneumoniae’
dır. Pnömokoklarda penisilin direnci son
yıllarda tüm dünyada ve Türkiye’de önemli bir endişe kaynağıdır. Penisiline
yüksek düzey dirençli pnömokok infeksiyonlarının tedavisinde üçüncü kuşak
sefalosporinler (seftriakson, sefotaksim) ve vankomisin kombinasyonu ile
birlikte deksametazon tedavisi tercih edilir.
Pnömokokal menenjitte tanı ve tedavide gecikme olması durumunda mortalite
oranı yüksektir. Bu yazıda, kronik alkol kullanımı öyküsü olan 40 yaşında bir
erkek hastada kafa travmasını takiben gelişen, geç tanı konulan ve mortal
seyreden penisiline dirençli Streptococcus
pneumoniae
menenjiti olgusu sunuldu.  

References

  • 1. Edward N. Janoff and Daniel M. Musher. Streptococcus pneumoniae. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Updated Edition, 2015; 2310-2327.e5.
  • 2. Van Veen KE, Brouwer MC, van der Ende A, van de Beek D. Bacterial meningitis in alcoholic patients: A population-based prospective study. J Infect 2017; 74 : 352-57.
  • 3. Kim AC, Epstein ME, Goyal PG, Doan TL. Infections in Alcoholic Liver Disease. Clin Liver Dis 2012; 16: 783–803.
  • 4. Leelarasamee A, Dhiraputra C, Hunnangkul S. Severe pneumococcal infection at a Thai hospital. Int J Infect Dis 1999; 3: 147-52.
  • 5. Weisfelt M, de Gans J, van der Ende A, van de Beek D. Community-acquired bacterial meningitis in alcoholic patients. PLoS One 2010; 5: 9102.
  • 6. Verghese VP, Veeraraghavan B, Jayaraman R, Varghese R, Neeravi A, Jayaraman Y, Thomas K, Mehendale SM. Increasing incidence of penicillin- and cefotaxime-resistant Streptococcus pneumoniae causing meningitis in India: Time for revision of treatment guidelines? Indian J Med Microbiol 2017; 35: 228-36.
  • 7. Cherazard R, Epstein M, Doan TL, Salim T, Bharti S, Smith MA. Antimicrobial Resistant Streptococcus pneumoniae: Prevalence, Mechanisms, and Clinical Implications. Am J Ther 2017 ; 24: 361-69.
  • 8. Muley VA, Ghadage DP, Yadav GE, Bhore AV. Study of Invasive Pneumococcal Infection in Adults with Reference to Penicillin Resistance. J Lab Physicians 2017 ; 9: 31-35.
  • 9. Erdem H, Elaldi N, Öztoprak N et al. Mortality indicators in pneumococcal meningitis: therapeutic implications. Int J Infect Dis 2014 ; 19: 13-19.
  • 10. Bijlsma M, Matthijs C Brouwer, E et al. Community-acquired bacterial meningitis in adults in the Netherlands, 2006–14: a prospective cohort study. Lancet Infect Dis 2016; 16: 339–47.
  • 11. Hameed N, Tunkel AR. Treatment of drug-resistant pneumococcal meningitis. Curr Infect Dis Rep 2010 ; 12: 274-81.
  • 12. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; 20thInformational Supplement, 2010, M100-S20. CLSI, Wayne, PA.
  • 13. Taşova Y, Saltoğlu N, Dündar İH. Çok ilaca dirençli pnömokokal menenjit: bir olgu sunumu.Flora Dergisi 1998; 3: 134-39.
There are 13 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Kader Arslan This is me

Salih Cesur

Şükran Sevim This is me

Ayşe Büyükdemirci This is me

Çiğdem Ataman Hatipoğlu This is me

Sami Kınıklı This is me

Publication Date December 28, 2018
Published in Issue Year 2018

Cite

APA Arslan, K., Cesur, S., Sevim, Ş., Büyükdemirci, A., et al. (2018). Kronik alkol kullanımı olan bir hastada kafa travmasını takiben gelişen penisiline dirençli pnömokok menenjiti. Turkish Journal of Clinics and Laboratory, 9(4), 357-360. https://doi.org/10.18663/tjcl.462004
AMA Arslan K, Cesur S, Sevim Ş, Büyükdemirci A, Hatipoğlu ÇA, Kınıklı S. Kronik alkol kullanımı olan bir hastada kafa travmasını takiben gelişen penisiline dirençli pnömokok menenjiti. TJCL. December 2018;9(4):357-360. doi:10.18663/tjcl.462004
Chicago Arslan, Kader, Salih Cesur, Şükran Sevim, Ayşe Büyükdemirci, Çiğdem Ataman Hatipoğlu, and Sami Kınıklı. “Kronik Alkol kullanımı Olan Bir Hastada Kafa travmasını Takiben gelişen Penisiline dirençli pnömokok Menenjiti”. Turkish Journal of Clinics and Laboratory 9, no. 4 (December 2018): 357-60. https://doi.org/10.18663/tjcl.462004.
EndNote Arslan K, Cesur S, Sevim Ş, Büyükdemirci A, Hatipoğlu ÇA, Kınıklı S (December 1, 2018) Kronik alkol kullanımı olan bir hastada kafa travmasını takiben gelişen penisiline dirençli pnömokok menenjiti. Turkish Journal of Clinics and Laboratory 9 4 357–360.
IEEE K. Arslan, S. Cesur, Ş. Sevim, A. Büyükdemirci, Ç. A. Hatipoğlu, and S. Kınıklı, “Kronik alkol kullanımı olan bir hastada kafa travmasını takiben gelişen penisiline dirençli pnömokok menenjiti”, TJCL, vol. 9, no. 4, pp. 357–360, 2018, doi: 10.18663/tjcl.462004.
ISNAD Arslan, Kader et al. “Kronik Alkol kullanımı Olan Bir Hastada Kafa travmasını Takiben gelişen Penisiline dirençli pnömokok Menenjiti”. Turkish Journal of Clinics and Laboratory 9/4 (December 2018), 357-360. https://doi.org/10.18663/tjcl.462004.
JAMA Arslan K, Cesur S, Sevim Ş, Büyükdemirci A, Hatipoğlu ÇA, Kınıklı S. Kronik alkol kullanımı olan bir hastada kafa travmasını takiben gelişen penisiline dirençli pnömokok menenjiti. TJCL. 2018;9:357–360.
MLA Arslan, Kader et al. “Kronik Alkol kullanımı Olan Bir Hastada Kafa travmasını Takiben gelişen Penisiline dirençli pnömokok Menenjiti”. Turkish Journal of Clinics and Laboratory, vol. 9, no. 4, 2018, pp. 357-60, doi:10.18663/tjcl.462004.
Vancouver Arslan K, Cesur S, Sevim Ş, Büyükdemirci A, Hatipoğlu ÇA, Kınıklı S. Kronik alkol kullanımı olan bir hastada kafa travmasını takiben gelişen penisiline dirençli pnömokok menenjiti. TJCL. 2018;9(4):357-60.


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