Platelet distribution width can be a useful marker of decreased platelet activity after percutaneous mitral balloon valvuloplasty

Year 2019, , 348 - 352, 30.09.2019

Müjgan Tek Mehmet Serkan Çetin

https://doi.org/10.18663/tjcl.542806

Abstract

Aim:
Increased platelet
activity and elevated mean platelet volume (MPV) has been
demonstrated in patients with rheumatic mitral stenosis (RMS).
However, platelet
distribution width (PDW) and the
impact of percutaneous mitral balloon valvuloplasty (PMBV) on PDW has
never been studied. Therefore, we aimed to investigate whether PMBV
decreases PDW in patients with RMS.

Material
and Methods:
Symptomatic patients with severe RMS undergoing PMBV were included.
Echocardiographic characteristics and hematologic parameters was
measured just before and 1 month after the PMBV procedure.

Results:
A total of 30 patients (24 female, mean age: 49.8±13.2 years) were
included the study. Mean transmitral pressure gradient, pulmonary
artery pressures and left atrium diameter decreased but mitral valve
area increased significantly after PMBV. PMBV procedure significantly
decreased PDW in patients with RMS (13.5±2.3 vs 12.4±1.9 fL, before
and after procedure, respectively; p<0.0001). MPV was decreased
after PMBV but it was not statistically significant (10.9±0.8 vs
10.6±0.9 fL, p=0.056). Platelet count was significantly increased
after procedure (250±62.6 vs 273.5±78.6 x103/ul, p=0.035). In
linear regression analysis, an independent relationship was found in
magnitude of PDW decrease and magnitude of increase in mitral valve
area (ẞ:0.491, p=0.046).

Conclusion:
PMBV
is associated with a significant decrease in PDW 1 month after the
procedure. There
was a significant correlation between the magnitude of decrease in
PDW and magnitude of increase in mitral valve area after PMBV.

Keywords

platelet distribution width, platelet activity, percutaneous mitral balloon valvuloplasty

Trombosit dağılım genişliği, perkütan mitral balon valvüloplasti sonrası azalmış trombosit aktivitesinin yararlı bir göstergesi olabilir

Abstract

Amaç:
Romatizmal
mitral darlığı (RMD) olan hastalarda artmış trombosit aktivitesi
ve yüksek ortalama trombosit hacmi (MPV) gösterilmiştir. Bununla
birlikte, trombosit dağılım genişliği (PDW) ve perkütan mitral
balon valvüloplasti'nin (PMBV) PDW üzerindeki etkisi hiç
çalışılmamıştır. Bu nedenle, RMD'lı hastalarda PMBV işleminin
PDW üzerine etkisini araştırmayı amaçladık.

Gereç
ve Yöntemler:
PMBV
uygulanan ciddi RMD'lı semptomatik hastalar dahil edildi.
Ekokardiyografik özellikler ve hematolojik parametreler PMBV
işleminden hemen önce ve bir ay sonra ölçüldü.

Bulgular:
Çalışmaya
toplam 30 hasta (24 kadın, ortalama yaş: 49,8 ± 13,2 yıl) dahil
edildi. Ortalama transmitral basınç gradyanı, pulmoner arter
basınçları ve sol atriyum çapı azaldı, ancak mitral kapak alanı
PMBV'den sonra anlamlı olarak arttı. PMBV prosedürü RMD'lı
hastalarda PDW'yi anlamlı şekilde azalttı (sırasıyla 13.5 ± 2.3
vs 12.4 ± 1.9 fL, prosedürden önce ve sonra; p <0.0001). MPV,
PMBV'den sonra azaldı, ancak istatistiksel olarak anlamlı değildi
(10.9 ± 0.8'e karşılık 10.6 ± 0.9 fL, p = 0.056). Trombosit
sayısı işlem sonrası anlamlı olarak arttı (250 ± 62.6 vs 273.5
± 78.6 x 103 / ul, p = 0.035). Lineer regresyon analizinde, PDW
azalmasının büyüklüğü ile mitral kapak alanındaki artışın
büyüklüğü arasında bağımsız bir ilişki bulundu (ẞ: 0.491,
p = 0.046).

Sonuç:
PMBV, işlemden 1 ay sonra PDW'de belirgin bir azalma ile
ilişkilidir. PMBV'den sonra PDW'deki düşüşün büyüklüğü ile
mitral kapak alanındaki artışın büyüklüğü arasında anlamlı
bir ilişki vardır.

Keywords

Trombosit dağılım genişliği, trombosit aktivitesi, perkütan mitral balon valvüloplasti

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