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The correlation between mitral annular calcification and prognostic nutritional index

Year 2019, , 452 - 458, 31.12.2019
https://doi.org/10.18663/tjcl.587533

Abstract

Aim:Prior studies have established the importance
of prognostic nutritional index (PNI) in patients with colorectal cancer and ST
elevation myocardial infarction. However, the relation ship between the nutritional
status and the mitral annular calcification (MAC) has not been investigated
yet. Hence, the aim of this study was to examine the relationship between the
presence of MAC
and the PNI.

Material and Methods:In total, 398 patients who were
admitted to our cardiology department were included in this retrospective analysis.
A total of 310 patients with MAC (+) constituted the study group, while 88
subjects without MAC (-) were accepted as a control group.Clinical characteristics
of the patients including age, sex, hypertension and diabetes mellitus were
retrieved from hospital electronic database. The
PNI was calculated using the following equation: 10×serum albumin (g/dL) +
0.005 × total lymphocyte count (per mm3).

Results:Serum albumin levels were found to be significantly lower in the MAC (+) group compared to the control group (3.76±0.57 vs. 4.12±0.31, p<0.001, respectively).  Total lymphocyte count of the MAC group was also significantly lower than the control group (1.86±0.63 vs. 2.02±0.66, p=0.05, respectively). Notably, the PNI of the MAC (+)group were significantly lower than the MAC (-) group (38.5 ± 5.8 vs. 42.2 ± 3.1; p <0.001, respectively). In correlation analysis, the PNI wasfoundto be negativelycorrelatedwiththepresence of MAC (r:-0.285; p<0.001).







Conclusion:We found that the presence of MAC
is significantly associated with lower levels of the PNI.

References

  • 1- D’Cruz I, Panetta F, Cohen H et al. Submitral calcification or sclerosis in elderly patients: M-mode and two-dimensional echocardiography in mitral anülüs calcification. Am J Cardiol 1979; 44: 31-38.
  • 2.Forman MB, Virmani R, Robertson RW. Mitral annular calcification in chronic renal failure. Arch Intern Med 1984; 85: 367-71.
  • 3.Labovitz JA, Nelson JG, Windhorst DM. Frequency of mitral valve dysfunction from mitral annular calcium as detected by Doppler echocardiography. Am J Cardiol 1985; 55: 133-37. 4-Aronow WS, Schwartz KS, Koenigsberg M. Correlation of serum lipids, calcium and phosphorus, diabetes mellitus, aortic valve stenosis and history of systemic hypertension with presence or absence of mitral anular calcium in persons older than 62 years in a long-term health care facility. Am J Cardiol 1987; 59: 381-82.
  • 5. Constans T, Bacq Y, Bréchot JF, Guimot JL, Choutet P, Lamisse F. Protein-energy malnutrition in elderly medical patients. J Am Geriatr Soc1992; 40: 263–68.
  • 6. Persson MD, Brismar KE, Katzarski KS, Nordenstrom J, Cederholm TE. Nutritional status using mini nutritional assessment and subjective global assessment predict mortality in geriatric patients. J Am Geriatr Soc 2002; 50: 1996–2002.
  • 7.Mohri T, Mohri Y, Shigemori T, Takeuchi K, Itoh Y, Kato T. Impact ofprognostic nutritional index on long-term outcomes in patients with breastcancer. World J Surg Oncol 2016; 14: 170.
  • 8.Tokunaga R, Sakamoto Y, Nakagawa S et al. Prognostic Nutritional Index Predicts Severe Complications, Recurrence and Poor Prognosis in Patients With Colorectal Cancer Undergoing Primary TumorResection. Dis Colon Rectum 2015; 58: 1048-57.
  • 9-Lang RM, Badano LP, Mor-Avi V et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal Cardiovascular Imaging 2015; 16: 233-70.
  • 10- Kohsaka S, Jin Z, Rundek Tet al. Impact of mitral annular calcification on cardiovascular events in a multiethnic community: the Northern Manhattan Study. JACC Cardiovasc Imaging 2008; 1: 617–23.
  • 11- Nestico PF, Depace NL, Morganroth J, Kotler MN, Ross J. Mitral annular calcification: clinical, pathophysiology, and echocardiographic review. American Heart Journal. 1984; 107: 989-96.
  • 12-Aronow WS. Mitral annular calcification: Significant and worth acting upon. Geriatrics 1991; 46: 73–86.
  • 13- Nair C.K, RuncoV.E ,Verson G.T. Conduction defects and mitral anülüs calcification. Br Heart J 1980; 44: 162–67.
  • 14-Feindel CM, Tufail Z, David TE, Ivanov J, Armstrong S. Mitral valve surgery in patients with extensive calcification of the mitral anülüs. J Thorac Cardiovasc Surg 2003; 126: 777-82.
  • 15-Eicher JC, Soto FX, De Nadai L, et al. Possible association of trombotic, nonbacterial vegetations of the mitral ring- mitral annular calcium and stroke. Am J Cardiol 1997; 79: 1712-15.
  • 16-Nair CK, Kudesia V, Hansen D, et al. Echocardiographic and electrocardiographic characteristics of patients with hypertrophic cardiomyopathy with and without mitral annular calcium. Am J Cardiol 1987; 59: 1428–30.
  • 17- Kurtoglu E, Korkmaz H, Akturk E, Yilmaz M, Altas Y, Uckan A. Association of mitral annulus calcification with high-sensitivity C-reactive protein, which is a marker of inflammation. Mediators of Inflammation 2012; 2012: 606207.
  • 18- Varol E, Aksoy F, Ozaydin M, Erdogan D, Dogan A. Association between neutrophil-lymphocyte ratio and mitral annular calcification. Blood Coagulation&Fibrinolysis 2014; 25: 557-60.
  • 19- Pamukcu HE, Aker M. Association between monocyte to HDL cholesterol ratio and mitral annulus calcification. J Surg Med 2019; 3: 44-48.
  • 20- Meakins J. Therapeutic approaches to anergy in surgical patients. Surgery and levamisole. Ann Surg 1979; 190: 286-88.
  • 21 - Buzby GP, Mullen JL, Matthews DC, Hobbs CL, Rosato EF. Prognostic nutritional index in gastrointestinal surgery. Am J Surg 1980; 139: 160-67.
  • 22- Buzby GP, Williford WO, Peterson OL. A randomized clinical trial of total parenteral nutrition in malnourished surgical patient: the rationale and impact of previous clinical trials and pilot study on protocol design. Am J Clin Nutr 1988; 47: 357-65.
  • 23- Gupta D, Lis CG. Pretreatment serum albumin as a predictor of cancer survival: a Systematic review of the epidemiological literature. Nutr J 2010; 9: 69
  • 24- Yang L, Xia, L, Wang Y et al. Low Prognostic Nutritional Index (PNI) Predicts Unfavorable Distant Metastasis-Free Survival in Nasopharyngeal Carcinoma: A Propensity Score-Matched Analysis. PLoS ONE 2016; 11: 158853
  • 25-Geng Y, Qi Q, Sun M, Chen H, Wang P, Chen Z. Prognostic nutritional index predicts survival and correlates with systemic inflammatory response in advanced pancreatic cancer. Eur J Surg Oncol 2015; 41: 1508-14.
  • 26-Ahn SS, Jung SM, Song JJ, Park YB, Lee SW. Prognostic nutritional index is correlated with disease activity in patients with systemic lupus erythematosus. Lupus 2018; 27: 1697-705.
  • 27-Doi S, Iwata H, Wada H et al. A novel and simply calculated nutritional index serves as a useful prognostic indicator in patients with coronary artery disease. Int J Cardiol 2018; 262: 92-98.
  • 28-Narumi T, Arimoto T, Funayama A et al. Prognostic importance of objective nutritional indexes in patients with chronic heart failure. J Cardiol 2013; 62: 307-13.

Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon

Year 2019, , 452 - 458, 31.12.2019
https://doi.org/10.18663/tjcl.587533

Abstract

Amaç: Hastaların nütrisyonel
durumu ve mitral anüler kalsifikasyon (MAK) arasında ilişki daha önce herhangi
bir şekilde ortaya konulamamıştır. Daha önceki çalışmalarda prognostik nütrisyonel
indeksinin (PNİ) kolorektal kanserli hastalardaoperasyon sonrası septik
komplikasyonlar ve ST yükselmeli miyokart enfarktüsü gibi birçok hastalıkta
prognostik öneme sahip olduğu gösterilmiştir. Bu çalışmanın amacı PNİ ile MAK
varlığı arasındaki ilişkiyi ortaya koymaktır.

Gereç ve Yöntemler: Bu retrospektif çalışmaya
ekokardiyografi laboratuvarına başvuran 398 hasta dahil edildi. MAK saptanan
310 hasta ile çalışma grubu,MAK saptanmayan 88 kişi ile kontrol grubu
oluşturuldu. Kontrol grubuna; yaş,cinsiyet,hipertansiyon ve diyabetesmellitus
varlığı gibi demografik özellikler açısından, MAK (+) grupla benzer özellikler
taşıyan hastalar dahil edildi. Laboratuvar parametreleri kaydedildi ve PNİ
değerleri hesaplandı.

Bulgular: Gruplar
arasında ortalama yaş, hipertansiyon ve diyabet varlığı açısından fark mevcut
değildi. Serum albümin düzeyleri MAK (+) grupta kontrol grubuna göre
istatistiki olarak anlamlı olacak şekilde daha düşük seviyelerde saptandı (3,76±0,57;
4,12 ±0,31,p<0,001). Lenfosit sayısı MAK (+) grupta kontrol grubuna göre
sınırda düşük saptandı (1,86±0,63; 2,02 ±0,66,p =0,05)Prognostik nütrisyonel
indeks, mitral anulus kalsifikasyonu saptanan hasta grubunda kontrol grubuna
göre anlamlı olarak düşük saptandı (38,5±5,8 ; 42,2±3.1 ,p <0,001).
Prognostik nütrisyonel düzeyi mitral anulus kalsifikasyonun bulunması açısından
istatiksel olarak anlamlı ve güçlü, bağımsız bir risk faktörü olarak saptandı.







Sonuç: Çalışmamız sonuç olarak MAK
varlığı ile PNİ birbiriyle ilişkili bulmuştur. MAK pozitifliği ile düşük
seviyedeki PNİ değeri istatistiksel olarak anlamlı bir şekilde ilişkili
bulunmuştur. 

References

  • 1- D’Cruz I, Panetta F, Cohen H et al. Submitral calcification or sclerosis in elderly patients: M-mode and two-dimensional echocardiography in mitral anülüs calcification. Am J Cardiol 1979; 44: 31-38.
  • 2.Forman MB, Virmani R, Robertson RW. Mitral annular calcification in chronic renal failure. Arch Intern Med 1984; 85: 367-71.
  • 3.Labovitz JA, Nelson JG, Windhorst DM. Frequency of mitral valve dysfunction from mitral annular calcium as detected by Doppler echocardiography. Am J Cardiol 1985; 55: 133-37. 4-Aronow WS, Schwartz KS, Koenigsberg M. Correlation of serum lipids, calcium and phosphorus, diabetes mellitus, aortic valve stenosis and history of systemic hypertension with presence or absence of mitral anular calcium in persons older than 62 years in a long-term health care facility. Am J Cardiol 1987; 59: 381-82.
  • 5. Constans T, Bacq Y, Bréchot JF, Guimot JL, Choutet P, Lamisse F. Protein-energy malnutrition in elderly medical patients. J Am Geriatr Soc1992; 40: 263–68.
  • 6. Persson MD, Brismar KE, Katzarski KS, Nordenstrom J, Cederholm TE. Nutritional status using mini nutritional assessment and subjective global assessment predict mortality in geriatric patients. J Am Geriatr Soc 2002; 50: 1996–2002.
  • 7.Mohri T, Mohri Y, Shigemori T, Takeuchi K, Itoh Y, Kato T. Impact ofprognostic nutritional index on long-term outcomes in patients with breastcancer. World J Surg Oncol 2016; 14: 170.
  • 8.Tokunaga R, Sakamoto Y, Nakagawa S et al. Prognostic Nutritional Index Predicts Severe Complications, Recurrence and Poor Prognosis in Patients With Colorectal Cancer Undergoing Primary TumorResection. Dis Colon Rectum 2015; 58: 1048-57.
  • 9-Lang RM, Badano LP, Mor-Avi V et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal Cardiovascular Imaging 2015; 16: 233-70.
  • 10- Kohsaka S, Jin Z, Rundek Tet al. Impact of mitral annular calcification on cardiovascular events in a multiethnic community: the Northern Manhattan Study. JACC Cardiovasc Imaging 2008; 1: 617–23.
  • 11- Nestico PF, Depace NL, Morganroth J, Kotler MN, Ross J. Mitral annular calcification: clinical, pathophysiology, and echocardiographic review. American Heart Journal. 1984; 107: 989-96.
  • 12-Aronow WS. Mitral annular calcification: Significant and worth acting upon. Geriatrics 1991; 46: 73–86.
  • 13- Nair C.K, RuncoV.E ,Verson G.T. Conduction defects and mitral anülüs calcification. Br Heart J 1980; 44: 162–67.
  • 14-Feindel CM, Tufail Z, David TE, Ivanov J, Armstrong S. Mitral valve surgery in patients with extensive calcification of the mitral anülüs. J Thorac Cardiovasc Surg 2003; 126: 777-82.
  • 15-Eicher JC, Soto FX, De Nadai L, et al. Possible association of trombotic, nonbacterial vegetations of the mitral ring- mitral annular calcium and stroke. Am J Cardiol 1997; 79: 1712-15.
  • 16-Nair CK, Kudesia V, Hansen D, et al. Echocardiographic and electrocardiographic characteristics of patients with hypertrophic cardiomyopathy with and without mitral annular calcium. Am J Cardiol 1987; 59: 1428–30.
  • 17- Kurtoglu E, Korkmaz H, Akturk E, Yilmaz M, Altas Y, Uckan A. Association of mitral annulus calcification with high-sensitivity C-reactive protein, which is a marker of inflammation. Mediators of Inflammation 2012; 2012: 606207.
  • 18- Varol E, Aksoy F, Ozaydin M, Erdogan D, Dogan A. Association between neutrophil-lymphocyte ratio and mitral annular calcification. Blood Coagulation&Fibrinolysis 2014; 25: 557-60.
  • 19- Pamukcu HE, Aker M. Association between monocyte to HDL cholesterol ratio and mitral annulus calcification. J Surg Med 2019; 3: 44-48.
  • 20- Meakins J. Therapeutic approaches to anergy in surgical patients. Surgery and levamisole. Ann Surg 1979; 190: 286-88.
  • 21 - Buzby GP, Mullen JL, Matthews DC, Hobbs CL, Rosato EF. Prognostic nutritional index in gastrointestinal surgery. Am J Surg 1980; 139: 160-67.
  • 22- Buzby GP, Williford WO, Peterson OL. A randomized clinical trial of total parenteral nutrition in malnourished surgical patient: the rationale and impact of previous clinical trials and pilot study on protocol design. Am J Clin Nutr 1988; 47: 357-65.
  • 23- Gupta D, Lis CG. Pretreatment serum albumin as a predictor of cancer survival: a Systematic review of the epidemiological literature. Nutr J 2010; 9: 69
  • 24- Yang L, Xia, L, Wang Y et al. Low Prognostic Nutritional Index (PNI) Predicts Unfavorable Distant Metastasis-Free Survival in Nasopharyngeal Carcinoma: A Propensity Score-Matched Analysis. PLoS ONE 2016; 11: 158853
  • 25-Geng Y, Qi Q, Sun M, Chen H, Wang P, Chen Z. Prognostic nutritional index predicts survival and correlates with systemic inflammatory response in advanced pancreatic cancer. Eur J Surg Oncol 2015; 41: 1508-14.
  • 26-Ahn SS, Jung SM, Song JJ, Park YB, Lee SW. Prognostic nutritional index is correlated with disease activity in patients with systemic lupus erythematosus. Lupus 2018; 27: 1697-705.
  • 27-Doi S, Iwata H, Wada H et al. A novel and simply calculated nutritional index serves as a useful prognostic indicator in patients with coronary artery disease. Int J Cardiol 2018; 262: 92-98.
  • 28-Narumi T, Arimoto T, Funayama A et al. Prognostic importance of objective nutritional indexes in patients with chronic heart failure. J Cardiol 2013; 62: 307-13.
There are 27 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Veysel Ozan Tanık 0000-0002-7193-4324

Hilal Erken Pamukçu 0000-0001-8116-5090

Publication Date December 31, 2019
Published in Issue Year 2019

Cite

APA Tanık, V. O., & Erken Pamukçu, H. (2019). Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon. Turkish Journal of Clinics and Laboratory, 10(4), 452-458. https://doi.org/10.18663/tjcl.587533
AMA Tanık VO, Erken Pamukçu H. Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon. TJCL. December 2019;10(4):452-458. doi:10.18663/tjcl.587533
Chicago Tanık, Veysel Ozan, and Hilal Erken Pamukçu. “Mitral anüler Kalsifikasyon Ile Prognostik Nutrisyonel Indeks arasındaki Koreleasyon”. Turkish Journal of Clinics and Laboratory 10, no. 4 (December 2019): 452-58. https://doi.org/10.18663/tjcl.587533.
EndNote Tanık VO, Erken Pamukçu H (December 1, 2019) Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon. Turkish Journal of Clinics and Laboratory 10 4 452–458.
IEEE V. O. Tanık and H. Erken Pamukçu, “Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon”, TJCL, vol. 10, no. 4, pp. 452–458, 2019, doi: 10.18663/tjcl.587533.
ISNAD Tanık, Veysel Ozan - Erken Pamukçu, Hilal. “Mitral anüler Kalsifikasyon Ile Prognostik Nutrisyonel Indeks arasındaki Koreleasyon”. Turkish Journal of Clinics and Laboratory 10/4 (December 2019), 452-458. https://doi.org/10.18663/tjcl.587533.
JAMA Tanık VO, Erken Pamukçu H. Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon. TJCL. 2019;10:452–458.
MLA Tanık, Veysel Ozan and Hilal Erken Pamukçu. “Mitral anüler Kalsifikasyon Ile Prognostik Nutrisyonel Indeks arasındaki Koreleasyon”. Turkish Journal of Clinics and Laboratory, vol. 10, no. 4, 2019, pp. 452-8, doi:10.18663/tjcl.587533.
Vancouver Tanık VO, Erken Pamukçu H. Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon. TJCL. 2019;10(4):452-8.


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