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Alopesi areata ve 25(OH) vitamin D

Year 2020, , 220 - 224, 30.09.2020
https://doi.org/10.18663/tjcl.756143

Abstract

Aim:To evaluate the status of serum 25-hydroxyvitamin D(25(OH)D) in patients with AA,serum 25(OH) D concentrations were compared with AA patients and healthy controls and thus determine if a possible association exists between serum 25(OH) D levels and AA.
Materials and Methods:The study comprising 43 patients diagnosed with AA and 69 healthy controls was conducted between October 2017 and March 2018.The serum vitamin D levels of the study group were determined by high performance liquid chromatography.Serum levels of calcium,phosphorus,alkaline phosphatase, and parathyroid hormone were also evaluated.
Results:The study was based on 43 patients aged between 10 and 47 (mean:33,41±7,2).The control group included 69 healthy persons aged between 18 and 55 (mean:33,53±7,2).Serum 25(OH)D levels in patients with AA ranged from 3,7 to 43,5 ng/ml with a mean of 20,21 ng/ml. Serum 25(OH)D levels in healthy controls ranged from 3 to 69,2 ng/ml with a mean of 24,09 ng/ml.There was no statistically difference in the serum vitamin D level between AA patients and healthy controls(p> 0.05)
Conclusion: In the light of these results, no relationship was found between AA and serum 25 (OH) vitamin D.

References

  • 1.Alkhalifah A, Alsantali A, Wang E et al. Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010; 62: 177–88.
  • 2.Gilhar A, Kalish RS. Alopecia areata: a tissue specific autoimmune disease of the hair follicle. Autoimmun Rev 2006; 5: 64–9.
  • 3.Kriegel MA, Manson JE, Costenbader KH. Does vitamin D affect risk of developing autoimmune disease? A systematic review. Semin Arthritis Rheum 2011; 40: 512–31.
  • 4.Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 2010; 39: 365–79.
  • 5.LoPiccolo MC, Lim HW. Vitamin D in health and disease. Photodermatol Photoimmunol Photomed 2010; 26: 224–9.
  • 6.Agmon-Levin N, Shoenfeld Y. Prediction and prevention of autoimmune skin disorder. Arch Dermatol Res 2009; 301: 57–64.
  • 7.Bergler-Czop B, Brzezińska-Wcisło L. Serum vitamin D level – the effect on the clinical course of psoriasis. Adv Dermatol Allergol 2016; 33: 445–9.
  • 8.Karagün E, Ergin C, Baysak S et al. The role of serum vitamin D levels in vitiligo. Adv Dermatol Allergol 2016; 33: 300–2.
  • 9.Kucharska A, Szmurło A, Sińska B. Significance of diet in treated and untreated acne vulgaris. Adv Dermatol Allergol 2016; 33: 81–6.
  • 10.Amano H, Abe M, Ishikawa O. First case report of topical tacalcitol for vitiligo repigmentation. Pediatr Dermatol 2008; 25: 262–4.
  • 11.Lips P, Hosking D, Lippuner K et al. The prevalance of vitamin D inadequacy among women with osteoporosis: an international epidemiological investigation. J Intern Med 2006; 260: 245–54.
  • 12.Yılmaz N, Serarslan G, Gokce C. Vitamin D concentrations are decreased in patients with alopecia areata. Vitam Trace Elem 2012; 1: 105–9.
  • 13.Mahamid M, Abu-Elhija O, Samamra M et al. Association between vitamin D levels and alopecia areata. Isr Med Assoc J 2014; 16: 367–70.
  • 14.Aksu Cerman A, Sarikaya Solak S, Kivanc Altunay I. Vitamin D deficiency in alopecia areata.Br J Dermatol.2014;170:1299–304.
  • 15.d’Ovidio R, Vessio M, d’Ovidio FD. Reduced level of 25-hydroxyvitamin D in chronic/relapsing alopecia areata.Dermatoendocrinol.2013;5:271–3.
  • 16.Marahatta S,Agrawal S,Khan S,et al.Study on Serum Vitamin D in Alopecia Areata Patients.J Nepal Health Res Counc.2019;17:21-5.
  • 17.gade VKV,Mony A,Munisamy M,et al.An investigation of vitamin D status in alopecia areata.Clin Exp Med.2018;18:577-84.
  • 18.Lee S,Kim BJ,Lee CH,et al.Increased prevalence of vitamin D deficiency in patients with alopecia areata:a systematic review and meta-analysis.J Eur Acad Dermatol Venereol.2018;32:1214-21.
  • 19.Hekimsoy Z, Dinç G, Kafesçiler S, et al. Vitamin D status among adults in the Aegean region of Turkey.BMC Public Health.2010;10:782.
  • 20.Orun E, Sezer S, Kanburoglu MK, et al. Vitamin D deficiency in healthy children and adolescent.Clin Invest Med.2015;38:E261–6.
  • 21.Van der Meer IM, Middelkoop BJ, Boeke AJ, Lips P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and Sub-Sahara African populations in Europe and their countries of origin: overview. Osteoporos Int 2011; 22: 1009–21.
  • 22.Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80: 1678–88.
  • 23.Gannagé-Yared MH, Chemali R, Yaacoub N et al. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J Bone Miner Res 2000; 15: 1856–62.
  • 24.Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women. Osteoporos Int 2001; 12: 931–5.
  • 25.Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol 2007; 103: 620–5.

Alopesi areata ile serum 25(OH) d vitamini ilişkisi

Year 2020, , 220 - 224, 30.09.2020
https://doi.org/10.18663/tjcl.756143

Abstract

Amaç:Alopesi areata(AA) hastalarında serum 25-hidroksivitamin D (25 (OH) D) seviyelerini incelemek ve sağlıklı bireylerden oluşan kontrol grubu ile karşılaştırarak serum 25 (OH) D seviyeleri ile AA arasında olası bir ilişki olup olmadığı belirlemektir.
Gereç ve Yöntemler: Ekim 2017-Mart 2018 tarihleri arasında AA tanısı konulan 43 hasta ve 69 sağlıklı birey çalışmaya alındı.Çalışma grubunun serum D vitamini düzeyleri yüksek performans likit kromatografi yöntemi ile değerlendirildi.Ayrıca serum kalsiyum, fosfor, alkalen fosfataz ve paratiroid hormon seviyeleri de değerlendirildi.
Bulgular: Çalışmamıza 10-47 yaş(ortalama: 33.41 ± 7.2) arasındaki 43 hasta ve kontrol grubunda 18-55 yaş arası(ortalama: 33,53 ± 7.2). 69 sağlıklı birey katılmıştır. AA'lı hastalarda serum 25 (OH) D seviyeleri ortalama 20,21 ng / ml (3,7-43,5 ng / ml) olarak belirlendi. Kontrol grubunda ise serum 25 (OH) D seviyeleri ortalama 24,09 ng /ml(3-69,2 ng / ml) olarak belirlendi.. Her iki grup arasında serum D vitamini düzeyi arasında istatistiksel olarak anlamlı bir fark yoktu(p> 0.05).
Sonuç: Bu sonuçlar ışığında AA ile serum 25(OH) D vitamini arasında herhangi bir ilişki saptanmamıştır.

References

  • 1.Alkhalifah A, Alsantali A, Wang E et al. Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010; 62: 177–88.
  • 2.Gilhar A, Kalish RS. Alopecia areata: a tissue specific autoimmune disease of the hair follicle. Autoimmun Rev 2006; 5: 64–9.
  • 3.Kriegel MA, Manson JE, Costenbader KH. Does vitamin D affect risk of developing autoimmune disease? A systematic review. Semin Arthritis Rheum 2011; 40: 512–31.
  • 4.Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 2010; 39: 365–79.
  • 5.LoPiccolo MC, Lim HW. Vitamin D in health and disease. Photodermatol Photoimmunol Photomed 2010; 26: 224–9.
  • 6.Agmon-Levin N, Shoenfeld Y. Prediction and prevention of autoimmune skin disorder. Arch Dermatol Res 2009; 301: 57–64.
  • 7.Bergler-Czop B, Brzezińska-Wcisło L. Serum vitamin D level – the effect on the clinical course of psoriasis. Adv Dermatol Allergol 2016; 33: 445–9.
  • 8.Karagün E, Ergin C, Baysak S et al. The role of serum vitamin D levels in vitiligo. Adv Dermatol Allergol 2016; 33: 300–2.
  • 9.Kucharska A, Szmurło A, Sińska B. Significance of diet in treated and untreated acne vulgaris. Adv Dermatol Allergol 2016; 33: 81–6.
  • 10.Amano H, Abe M, Ishikawa O. First case report of topical tacalcitol for vitiligo repigmentation. Pediatr Dermatol 2008; 25: 262–4.
  • 11.Lips P, Hosking D, Lippuner K et al. The prevalance of vitamin D inadequacy among women with osteoporosis: an international epidemiological investigation. J Intern Med 2006; 260: 245–54.
  • 12.Yılmaz N, Serarslan G, Gokce C. Vitamin D concentrations are decreased in patients with alopecia areata. Vitam Trace Elem 2012; 1: 105–9.
  • 13.Mahamid M, Abu-Elhija O, Samamra M et al. Association between vitamin D levels and alopecia areata. Isr Med Assoc J 2014; 16: 367–70.
  • 14.Aksu Cerman A, Sarikaya Solak S, Kivanc Altunay I. Vitamin D deficiency in alopecia areata.Br J Dermatol.2014;170:1299–304.
  • 15.d’Ovidio R, Vessio M, d’Ovidio FD. Reduced level of 25-hydroxyvitamin D in chronic/relapsing alopecia areata.Dermatoendocrinol.2013;5:271–3.
  • 16.Marahatta S,Agrawal S,Khan S,et al.Study on Serum Vitamin D in Alopecia Areata Patients.J Nepal Health Res Counc.2019;17:21-5.
  • 17.gade VKV,Mony A,Munisamy M,et al.An investigation of vitamin D status in alopecia areata.Clin Exp Med.2018;18:577-84.
  • 18.Lee S,Kim BJ,Lee CH,et al.Increased prevalence of vitamin D deficiency in patients with alopecia areata:a systematic review and meta-analysis.J Eur Acad Dermatol Venereol.2018;32:1214-21.
  • 19.Hekimsoy Z, Dinç G, Kafesçiler S, et al. Vitamin D status among adults in the Aegean region of Turkey.BMC Public Health.2010;10:782.
  • 20.Orun E, Sezer S, Kanburoglu MK, et al. Vitamin D deficiency in healthy children and adolescent.Clin Invest Med.2015;38:E261–6.
  • 21.Van der Meer IM, Middelkoop BJ, Boeke AJ, Lips P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and Sub-Sahara African populations in Europe and their countries of origin: overview. Osteoporos Int 2011; 22: 1009–21.
  • 22.Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004; 80: 1678–88.
  • 23.Gannagé-Yared MH, Chemali R, Yaacoub N et al. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J Bone Miner Res 2000; 15: 1856–62.
  • 24.Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women. Osteoporos Int 2001; 12: 931–5.
  • 25.Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol 2007; 103: 620–5.
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Erdinç Terzi

Publication Date September 30, 2020
Published in Issue Year 2020

Cite

APA Terzi, E. (2020). Alopesi areata ile serum 25(OH) d vitamini ilişkisi. Turkish Journal of Clinics and Laboratory, 11(4), 220-224. https://doi.org/10.18663/tjcl.756143
AMA Terzi E. Alopesi areata ile serum 25(OH) d vitamini ilişkisi. TJCL. September 2020;11(4):220-224. doi:10.18663/tjcl.756143
Chicago Terzi, Erdinç. “Alopesi Areata Ile Serum 25(OH) D Vitamini ilişkisi”. Turkish Journal of Clinics and Laboratory 11, no. 4 (September 2020): 220-24. https://doi.org/10.18663/tjcl.756143.
EndNote Terzi E (September 1, 2020) Alopesi areata ile serum 25(OH) d vitamini ilişkisi. Turkish Journal of Clinics and Laboratory 11 4 220–224.
IEEE E. Terzi, “Alopesi areata ile serum 25(OH) d vitamini ilişkisi”, TJCL, vol. 11, no. 4, pp. 220–224, 2020, doi: 10.18663/tjcl.756143.
ISNAD Terzi, Erdinç. “Alopesi Areata Ile Serum 25(OH) D Vitamini ilişkisi”. Turkish Journal of Clinics and Laboratory 11/4 (September 2020), 220-224. https://doi.org/10.18663/tjcl.756143.
JAMA Terzi E. Alopesi areata ile serum 25(OH) d vitamini ilişkisi. TJCL. 2020;11:220–224.
MLA Terzi, Erdinç. “Alopesi Areata Ile Serum 25(OH) D Vitamini ilişkisi”. Turkish Journal of Clinics and Laboratory, vol. 11, no. 4, 2020, pp. 220-4, doi:10.18663/tjcl.756143.
Vancouver Terzi E. Alopesi areata ile serum 25(OH) d vitamini ilişkisi. TJCL. 2020;11(4):220-4.


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