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Kronik Viral Hepatit B ve C’de Serum Leptin Düzeyinin Önemi. The Importance of Serum Leptin Level in Chronic Viral Hepatitis B and C

Yıl 2021, Cilt: 4 Sayı: 1, 14 - 19, 30.04.2021
https://doi.org/10.33713/egetbd.880183

Öz

Objective: Leptin plays an important role in inflammation and liver fibrogenesis in viral liver diseases. In this study, determination of serum leptin level and the effect of leptin levels on liver inflammation and fibrosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) cases were evaluated.
Materials and Methods: The study groups consisted of 75 CHB, 36 CHC patients and 51 healthy subjects were included in the study as the control group. Liver biopsy specimens were scored using Ishak histological scoring system. Serum leptin levels were determined by ELISA method.
Results: 39 of the chronic hepatitis B cases were female, 36 were male, 18 of the CHC cases were female, 18 were male, and 26 of the control group were female 25 one was male. Serum leptin levels were statistically significantly higher in CHB and CHC cases than in the control group (p: 0.001). However, there was no statistically significant difference in serum leptin level between CHC and CHB cases. There was no statistically significant difference between serum leptin levels and age, gender, and biochemical parameters (P> 0.05). Serum leptin levels were statistically significantly higher in patients with significant fibrosis in chronic hepatitis B and KHC patients compared to those with mild fibrosis.
Conclusion: Leptin plays a role in liver inflammation and fibrosis in CHB and CHC. Leptin level indicates advanced fibrosis. In CHB and CHC patients, leptin levels can be used to evaluate the degree of advanced fibrosis and in clinical follow-up, but larger studies are needed.

Kaynakça

  • 1. Zeybekoğlu G, Kılıç N, Yıldırım Z, Özer Ç, Babül A. Effects of leptin in rat liver antioxidant systems. Turkish Journal of Biochemistry. 2012; 37 (4): 452–456.
  • 2. Chang ML, Kuo CJ, Huang HC, Chu YY, Chiu CT. Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance:Homeostasis of Metabolism and Immunity. PLoS ONE. 2016; 11(11): 1-12.
  • 3. Haghgoo SM, Sharafi H, Alavian SM. Serum cytokines, adipokines and ferritin for non-invasive assessment of liver fibrosis in chronic liver disease: a systematic review. Clin Chem Lab Med. 2019; 57(5): 577–610.
  • 4. Keleş V, Büyükgüzel K, Büyükgüzel E. Leptin and Role in Metabolic RegulationTurkish Journal of Diabetes and Obesity. 2018; 1: 17-22.
  • 5. Pavlidis C, Panoutsopoulos GI, Tiniakos D, Koutsounas S, Vlachogiannakos J, Vafiadis IZ. Serum leptin and ghrelin in chronic hepatitis C patients with steatosis. World J Gastroenterol. 2011; 17(46): 5097-5104.
  • 6. Chang ML, Kuo CJ, Huang HC, Chu YY, Chiu CT. Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance: Homeostasis of Metabolism and Immunity. PLoS ONE.2016; 11(11): 1-12.
  • 7. Lampertico P. European Association for the study of the liver (EASL) 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. Available from: URL:http://www.easl.eu/medias/cpg/management-of-hepatitis-B-virus-infection/English-eport.pdf.
  • 8. Balkan A, Gülşen MT, Balkan Y, Çalı SK. Relationship between the frequency of hepatitis B virüs infections and levels of serum adipokines in patients with hepatosteatosis and insulin resistance. Eur J Ther. 2017; 23: 60-6.
  • 9. Rotundo L, Persaud A, Feurdean M, Ahlawat S, Kim HS. The association of leptin with severity of non-alcoholic fatty liver disease: A population-based study Clinical and Molecular Hepatology. 2018; 24: 392-401.
  • 10. Buechler C, Haberl EM, Fischboeck LR, Aslanidis C. Adipokines in Liver Cirrhosis. International Journal of Molecular Sciences. Int. J. Mol. Sci. 2017; 18: 1392. 11. Polyzos SA, Aronis KN, Kountouras J, Raptis DD, Vasiloglou MF, Mantzoros CS. Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis. Diabetologia. 2016; 59: 30-43.
  • 12. Korah TE, Sayed SE, ElShafie MK, Hammoda GE, Safan MA. Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis. World J Hepatol. 2013; 5(2): 74-81.
  • 13. Reimers EG, Platt GQ, Gaspar MR, Valls RA, Hernández OP, Fernández FS. Liver steatosis in hepatitis C patients. World J Hepatol. 2015; 7(10): 1337-1346. 14. Altıntaş E, Aslan G, Sezgin O, Üçbilek E, Emektar G, Gezer D. Increased serum leptin concentration is related to steatosis in hepatitis C virus-infected patients. Academic journal of gastroenterology. 2011; 10 (3): 97-103.
  • 15. Khattab MA, Eslam M, Shatat M, Aalhalim HA, Mousa YI, Samir F, et al. Changes in Adipocytokines and Insulin Sensitivity during and after Antiviral Therapy for Hepatitis C Genotype 4. J Gastrointestin Liver Dis. 2012; 21(1): 59-65.
  • 16. Aşçı Z, Demirtürk N, Demirdal T, Acartürk G, Aktepe OC, Doğan N, et al. Kronik Viral Hepatitli Hastalarda Serum Fibrozis Belirleyicilerinin (Endoglin, Leptin ve İmmunoglobulinler) Karaciğer Histopatolojisi ile Uyumu. Turkey Clinics J Med Sci. 2012; 32(6): 1569-75.
  • 17. Kumar R, Prakash S, Chhabra S, Singla V, Madan K, Gupta SD, et al. Association of pro-inflammatory cytokines, adipokines & oxidative stress with insulin resistance & non-alcoholic fatty liver disease. Indian J Med Res. 2012; 136: 229-236.
  • 18. Kukla M, Mazur W, Buldak RJ, Korczala KZ. Potential Role of Leptin, Adiponectin and Three Novel Adipokines-Visfatin, Chemerin and Vaspin in Chronic Hepatitis. Mol Med. 2011; 17 (11-12): 1397- 1410.

The Importance of Serum Leptin Level in Chronic Viral Hepatitis B and C

Yıl 2021, Cilt: 4 Sayı: 1, 14 - 19, 30.04.2021
https://doi.org/10.33713/egetbd.880183

Öz

OBJECTIVE: Leptin plays an important role in inflammation and liver fibrogenesis in viral liver diseases. In this study, determination of serum leptin level and the effect of leptin levels on liver inflammation and fibrosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) cases were evaluated.
MATERIALS AND METHODS: In this prospective clinical research study, a total of 75 CHB patients, 36 CHC patients, and a 51 control group were included. Liver biopsy specimens were scored using Ishak histological scoring system. Serum leptin levels were determined by ELISA method.
RESULTS: Overall, 39 of CHB cases were female while 36 was male, there were 18 female and 18 male cases of CHC, while the control group consisted of 26 female and 25 male. Serum leptin levels were statistically significantly higher in CHB (2.81±0.38) and CHC (2.97±0.35) cases than in the control group (1.39±0.08) (p: 0.001). However, there was no statistically significant difference in serum leptin level between CHC and CHB cases. There was no statistically significant difference between serum leptin levels and age, gender, and biochemical parameters (P> 0.05). Serum leptin levels were statistically significantly higher in patients with significant fibrosis in chronic hepatitis B and KHC patients compared to those with mild fibrosis (P<0.05).
CONCLUSION: Leptin plays a role in liver inflammation and fibrosis in CHB and CHC. In CHB and CHC patients, leptin levels can be used to evaluate the degree of advanced fibrosis and in clinical follow-up, but larger studies are needed.

Kaynakça

  • 1. Zeybekoğlu G, Kılıç N, Yıldırım Z, Özer Ç, Babül A. Effects of leptin in rat liver antioxidant systems. Turkish Journal of Biochemistry. 2012; 37 (4): 452–456.
  • 2. Chang ML, Kuo CJ, Huang HC, Chu YY, Chiu CT. Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance:Homeostasis of Metabolism and Immunity. PLoS ONE. 2016; 11(11): 1-12.
  • 3. Haghgoo SM, Sharafi H, Alavian SM. Serum cytokines, adipokines and ferritin for non-invasive assessment of liver fibrosis in chronic liver disease: a systematic review. Clin Chem Lab Med. 2019; 57(5): 577–610.
  • 4. Keleş V, Büyükgüzel K, Büyükgüzel E. Leptin and Role in Metabolic RegulationTurkish Journal of Diabetes and Obesity. 2018; 1: 17-22.
  • 5. Pavlidis C, Panoutsopoulos GI, Tiniakos D, Koutsounas S, Vlachogiannakos J, Vafiadis IZ. Serum leptin and ghrelin in chronic hepatitis C patients with steatosis. World J Gastroenterol. 2011; 17(46): 5097-5104.
  • 6. Chang ML, Kuo CJ, Huang HC, Chu YY, Chiu CT. Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance: Homeostasis of Metabolism and Immunity. PLoS ONE.2016; 11(11): 1-12.
  • 7. Lampertico P. European Association for the study of the liver (EASL) 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. Available from: URL:http://www.easl.eu/medias/cpg/management-of-hepatitis-B-virus-infection/English-eport.pdf.
  • 8. Balkan A, Gülşen MT, Balkan Y, Çalı SK. Relationship between the frequency of hepatitis B virüs infections and levels of serum adipokines in patients with hepatosteatosis and insulin resistance. Eur J Ther. 2017; 23: 60-6.
  • 9. Rotundo L, Persaud A, Feurdean M, Ahlawat S, Kim HS. The association of leptin with severity of non-alcoholic fatty liver disease: A population-based study Clinical and Molecular Hepatology. 2018; 24: 392-401.
  • 10. Buechler C, Haberl EM, Fischboeck LR, Aslanidis C. Adipokines in Liver Cirrhosis. International Journal of Molecular Sciences. Int. J. Mol. Sci. 2017; 18: 1392. 11. Polyzos SA, Aronis KN, Kountouras J, Raptis DD, Vasiloglou MF, Mantzoros CS. Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis. Diabetologia. 2016; 59: 30-43.
  • 12. Korah TE, Sayed SE, ElShafie MK, Hammoda GE, Safan MA. Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis. World J Hepatol. 2013; 5(2): 74-81.
  • 13. Reimers EG, Platt GQ, Gaspar MR, Valls RA, Hernández OP, Fernández FS. Liver steatosis in hepatitis C patients. World J Hepatol. 2015; 7(10): 1337-1346. 14. Altıntaş E, Aslan G, Sezgin O, Üçbilek E, Emektar G, Gezer D. Increased serum leptin concentration is related to steatosis in hepatitis C virus-infected patients. Academic journal of gastroenterology. 2011; 10 (3): 97-103.
  • 15. Khattab MA, Eslam M, Shatat M, Aalhalim HA, Mousa YI, Samir F, et al. Changes in Adipocytokines and Insulin Sensitivity during and after Antiviral Therapy for Hepatitis C Genotype 4. J Gastrointestin Liver Dis. 2012; 21(1): 59-65.
  • 16. Aşçı Z, Demirtürk N, Demirdal T, Acartürk G, Aktepe OC, Doğan N, et al. Kronik Viral Hepatitli Hastalarda Serum Fibrozis Belirleyicilerinin (Endoglin, Leptin ve İmmunoglobulinler) Karaciğer Histopatolojisi ile Uyumu. Turkey Clinics J Med Sci. 2012; 32(6): 1569-75.
  • 17. Kumar R, Prakash S, Chhabra S, Singla V, Madan K, Gupta SD, et al. Association of pro-inflammatory cytokines, adipokines & oxidative stress with insulin resistance & non-alcoholic fatty liver disease. Indian J Med Res. 2012; 136: 229-236.
  • 18. Kukla M, Mazur W, Buldak RJ, Korczala KZ. Potential Role of Leptin, Adiponectin and Three Novel Adipokines-Visfatin, Chemerin and Vaspin in Chronic Hepatitis. Mol Med. 2011; 17 (11-12): 1397- 1410.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Orijinal Araştırma
Yazarlar

Arzu Şenol 0000-0002-8537-0195

Zülal Aşcı Toraman

Yayımlanma Tarihi 30 Nisan 2021
Kabul Tarihi 18 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 4 Sayı: 1

Kaynak Göster

EndNote Şenol A, Aşcı Toraman Z (01 Nisan 2021) The Importance of Serum Leptin Level in Chronic Viral Hepatitis B and C. Ege Tıp Bilimleri Dergisi 4 1 14–19.

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