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1H, 1'H-3,3'-Biindazol Maddesinin Ratlarda Bazı Biyokimyasal Parametrelere Etkisinin Araştırılması

Year 2022, , 152 - 159, 30.06.2022
https://doi.org/10.35193/bseufbd.999490

Abstract

İndazoller kimya ve farmakoloji’de önemli bileşiklerdir. Bu çalışmada, ratlara belirli sürelerde enjekte edilen 1H,1'H-3,3'-biindazol maddesinin, ratların kan serumu, karaciğer ve böbrekteki antioksidan vitaminler (A, E, C), Se, MDA miktarları ile GSH-Px enzim aktiviteleri üzerine etkilerinin araştırılması amaçlanmıştır. Serum, karaciğer ve böbrek numunelerindeki selenyum miktarları florimetrik metotla, A, E, C ve MDA seviyeleri ise yüksek performanslı sıvı kromatografisi (HPLC) ile belirlenmiştir. Eritrositlerin GSH-Px enzim aktivite miktarları spektrofotometrik metotla ölçülmüştür. Deneysel sonuçlarımız, A, E, C vitaminleri ve Se düzeylerinin genel olarak kontrol grubuna göre daha düşük olduğu, 3. enjeksiyon periyodunda GSH-Px enzim aktivite miktarının maksimum arttığı ve diğer enjeksiyon periyodlarındaki aktivitelerin kontrol grubuna göre daha yüksek olduğu gözlenmiştir. 1H,1'H-3,3'-biindazolmaddesi uygulamasından sonra ratların A, E, C vitaminleri ve Se düzeyleri azalırken, MDA seviyeleri ve GSH-Px enzim aktivite miktarlarının arttığı tespit edilmiştir. Pek çok hastalığın tedavisinde kullanılan bu tıbbi maddelerin hayati önem taşıdığı ancak metabolizmada oksidatif strese yol açtığı belirlenmiştir. Bu maddeleri içeren ilaçların kullanımlarında antioksidan vitaminlerin ve selenium desteğinin faydalı olabileceği kanaatine varılmıştır.

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Investigation of the Effect of 1H, 1'H-3,3'-Biindazole on Some Biochemical Parameters in Rats

Year 2022, , 152 - 159, 30.06.2022
https://doi.org/10.35193/bseufbd.999490

Abstract

Indazoles are important compounds for chemistry and pharmacology. This study aimed to investigate the amount of antioxidant vitamins (A, E, C), Se, MDA and GSH-Px enzyme activities in the blood serum liver and kidneys of rats the 1H,1'H-3,3'-biindazole injected into rats for certain periods. Amounts of selenium in serum, liver and kidney samples were determined by fluorimetric method, A, E, C, and MDA levels were determined by high performance liquid chromatography (HPLC). GSH-Px enzyme activity amounts of erythrocytes were measured by spectrophotometric method. In our experimental results, it was observed that the levels of vitamins A, E, C, and Se were generally lower than the control group, maximum increase in the amount of GSH-Px enzyme activity in the 3rd injection period and the activities in the other injection periods were higher than the control group. It was determined that levels of decreased vitamin A, E, C, and Se while increased of levels MDA and GSH-Px enzyme activity. It has been determined that these medicinal substances used in the treatment of many diseases are vital; however, it causes oxidative stress in metabolism. It has been concluded that it may be useful beneficial of supplements antioxidant vitamins and selenium in the use of drugs containing these substances.

References

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  • Schmidt, A., Beutler, B., & Snovydovych, B. (2008). Recent advances in the chemistry of indazoles. European Journal of Organic Chemistry, 4073-4095. Denya, I., Malan, S.F., & Joubert, J. (2018). Indazole derivatives and their therapeutic applications: a patent review (2013–2017). Expert Opinion on Therapeutic Patents, 28, 441–53.
  • Dong, J., Zhang, Q., Wang, Z., Huang, G., & Li, S. (2018). Recent advances in the development of indazole based anticancer agents. Chem Med Chem, 13, 1490–507.
  • Dong, J., Zhang, Q., Wang, Z., Huang, G., & Li, S. (2018). Recent advances in the development of indazole based anticancer agents. Chem Med Chem, 13, 1490–507.
  • Elguero, J., Fruchier, A., Tjiou, E.M., & Trofimenko, S. (1995). 13C NMR of indazoles. Chemistry of Heterocyclic Compounds, 31, 1006-1026.
  • Elguero, J., Fruchier, A., Tjiou, E.M., & Trofimenko, S. (1995). 13C NMR of indazoles. Chemistry of Heterocyclic Compounds, 31, 1006-1026.
  • Mosti, L., Menozzi, G., Fossa, P., Filippelli, W., Gessi, S., Rinaldi, B., & Falcone, G. (2000). Synthesis and preliminary biological evaluation of novel N-substituted 1-amino-3-[1- methyl (phenyl)-1H indazol 4-yloxy]-propan-2-ols interesting as potential antiarrhythmic, local anesthetic and analgesic agents. Arzneimittelforschung, 50, 963- 972.
  • Mosti, L., Menozzi, G., Fossa, P., Filippelli, W., Gessi, S., Rinaldi, B., & Falcone, G. (2000). Synthesis and preliminary biological evaluation of novel N-substituted 1-amino-3-[1- methyl (phenyl)-1H indazol 4-yloxy]-propan-2-ols interesting as potential antiarrhythmic, local anesthetic and analgesic agents. Arzneimittelforschung, 50, 963- 972.
  • Ali, N.A., Dar, B.A., Pradhan, V., & Farooqui, M. (2013). Chemistry and biology of indoles and indazoles: amini-review. Mini- Reviews in Medicinal Chemistry, 13(12), 1792-800.
  • Ali, N.A., Dar, B.A., Pradhan, V., & Farooqui, M. (2013). Chemistry and biology of indoles and indazoles: amini-review. Mini- Reviews in Medicinal Chemistry, 13(12), 1792-800.
  • Wang, Y., Yan, M., Ma, R., & Ma, S. (2015). Synthesis and Antibacterial Activity of Novel 4 Bromo-1H Indazole Derivatives as FtsZ Inhibitors. Arch. Pharm Chemistry in Life Sciences, 348, 266-274.
  • Wang, Y., Yan, M., Ma, R., & Ma, S. (2015). Synthesis and Antibacterial Activity of Novel 4 Bromo-1H Indazole Derivatives as FtsZ Inhibitors. Arch. Pharm Chemistry in Life Sciences, 348, 266-274.
  • Gopalakrishnan, M., Sureshkumar, P., Thanusu, J., & Kanagarajan, V. (2008). Synthesis, spectral analysis, antibacterial and antifungal activities of some 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazole- a novel fused indazole derivative. Journal of Enzyme Inhibition and Medicinal Chemistry, 23, 974-979.
  • Gopalakrishnan, M., Sureshkumar, P., Thanusu, J., & Kanagarajan, V. (2008). Synthesis, spectral analysis, antibacterial and antifungal activities of some 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazole- a novel fused indazole derivative. Journal of Enzyme Inhibition and Medicinal Chemistry, 23, 974-979.
  • Lin, S., Zhang, F., Jiang, G., Qureshi, S. A., Yang, X., Chicchi, G. G., Tota, L., Bansal, A., Brady, E., Trujillo, M., Salituro, G., Miller, C., Tata, J. R., Zhang, B. B., & Parmee, E. R. (2015). A novel series of indazole-/indole based glucagon receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 25, 4143–4147.
  • Lin, S., Zhang, F., Jiang, G., Qureshi, S. A., Yang, X., Chicchi, G. G., Tota, L., Bansal, A., Brady, E., Trujillo, M., Salituro, G., Miller, C., Tata, J. R., Zhang, B. B., & Parmee, E. R. (2015). A novel series of indazole-/indole based glucagon receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 25, 4143–4147.
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  • Zhang, H. C., Derian, C. K., Andrade-Gordon, P., Hoekstra, W. J., McComsey, D. F., White, K. B., Poulter, B. L., Addo, M. F., Cheung, W. M., Damiano, B. P., Oksenberg, D., Reynolds, E. E., Pandey, A., Scarborough, R. M., & Maryanoff, B. E. (2001). Discovery and optimization of a novel series of thrombin receptor (PAR-1) antagonists: Potent, selective peptide mimetics based on indole and indazole templates. Journal of Medicinal Chemistry, 44(7), 1021-1024.
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There are 68 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Ebru Çöteli 0000-0002-9473-0914

Fikret Karataş 0000-0002-0884-027X

Haki Kara 0000-0002-0295-0582

Süleyman Servi 0000-0003-0827-8624

Publication Date June 30, 2022
Submission Date September 22, 2021
Acceptance Date January 19, 2022
Published in Issue Year 2022

Cite

APA Çöteli, E., Karataş, F., Kara, H., Servi, S. (2022). 1H, 1’H-3,3’-Biindazol Maddesinin Ratlarda Bazı Biyokimyasal Parametrelere Etkisinin Araştırılması. Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi, 9(1), 152-159. https://doi.org/10.35193/bseufbd.999490